Millimetre-scale MICrONS connectomic-functional data extend the like-to-like ru…

Millimetre-scale MICrONS connectomic-functional data extend the like-to-like rule beyond local L2/3 pairs: feature-tuned similarity predicts connectivity within and across cortical layers and across visual areas, including feedback projections.

{
  "n": 0,
  "doi": "10.1038/s41586-025-08840-3",
  "claim": "Millimetre-scale MICrONS connectomic-functional data extend the like-to-like rule beyond local L2/3 pairs: feature-tuned similarity predicts connectivity within and across cortical layers and across visual areas, including feedback projections.",
  "cite_key": "Ding2025",
  "evidence": "Co-registered two-photon functional imaging and large-volume serial-section EM of mouse visual cortex. Feature vs spatial RF components separated via a digital-twin model; only feature similarity predicted fine-scale connectivity beyond axon–dendrite proximity.",
  "effect_size": "Pairwise like-to-like preserved across layers/areas; additional higher-order rule (postsynaptic cohorts share tuning more than pairwise rule predicts)",
  "text_access": "abstract_only",
  "study_system": "mouse visual cortex (V1 + higher visual areas); MICrONS millimetre-scale functional connectomics",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "Our results reveal that neurons with similar response properties are preferentially connected within and across layers and areas-including feedback connections-supporting the universality of 'like-to-like' connectivity across the visual hierarchy.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.1038/nature09880",
    "10.1038/nature14182",
    "10.1038/nature17192"
  ],
  "effect_size_source_sentence": "We also discovered a higher-order rule whereby postsynaptic neuron cohorts downstream of presynaptic cells show greater functional similarity than predicted by a pairwise like-to-like rule."
}

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Our results reveal that neurons with similar response properties are preferentially connected within and across layers and areas-including feedback connections-supporting the universality of 'like-to-like' connectivity across the visual hierarchy.

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Co-registered two-photon functional imaging and large-volume serial-section EM of mouse visual cortex. Feature vs spatial RF components separated via a digital-twin model; only feature similarity predicted fine-scale connectivity beyond axon–dendrite proximity.