Mouse auditory cortex layer 4 contains a class of pyramidal neurons (CS-L4) tha…

Mouse auditory cortex layer 4 contains a class of pyramidal neurons (CS-L4) that receive direct thalamic input and project long-range to the posterior striatum, violating the canonical assumption that L4 makes only local intracortical connections.

{
  "n": 0,
  "doi": "10.1523/jneurosci.1738-21.2021",
  "claim": "Mouse auditory cortex layer 4 contains a class of pyramidal neurons (CS-L4) that receive direct thalamic input and project long-range to the posterior striatum, violating the canonical assumption that L4 makes only local intracortical connections.",
  "cite_key": "Bertero2022",
  "evidence": "Retrograde tracing, whole-cell patch-clamp electrophysiology and optogenetic activation of thalamic and L4 inputs in mouse auditory cortex.",
  "effect_size": "Existence of distinct CS-L4 long-range projection neurons in L4 (qualitative).",
  "text_access": "abstract_only",
  "study_system": "Mouse primary auditory cortex; retrograde tracing from posterior striatum; in vitro electrophysiology and optogenetics in L4 pyramidal neurons",
  "argument_role": "supporting",
  "replication_status": "single_study",
  "claim_source_sentence": "Here, taking advantage of anatomic, electrophysiological, and optogenetic techniques, we describe, for the first time, a long-range corticostriatal class of pyramidal neurons in layer 4 (CS-L4) of the mouse auditory cortex that receive direct thalamic inputs.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

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]

Here, taking advantage of anatomic, electrophysiological, and optogenetic techniques, we describe, for the first time, a long-range corticostriatal class of pyramidal neurons in layer 4 (CS-L4) of the mouse auditory cortex that receive direct thalamic inputs.

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