Version history

{
  "scope": "human, resting-state fMRI in first-episode schizophrenia",
  "claim_text": "In first-episode treatment-naive schizophrenia, resting-state functional connectivity is selectively reduced in the limbic frontostriatal loop—not the sensorimotor or associative loops—linking parallel-loop dysfunction to disorganization symptoms.",
  "raw_fields": {
    "n": 66,
    "doi": "10.1002/hbm.23879",
    "claim": "In first-episode treatment-naive schizophrenia, resting-state functional connectivity is selectively reduced in the limbic frontostriatal loop—not the sensorimotor or associative loops—linking parallel-loop dysfunction to disorganization symptoms.",
    "cite_key": "Lin2017",
    "evidence": "Resting-state fMRI in 37 first-episode schizophrenia patients vs 29 healthy controls with seed-based connectivity to six striatal subregions identified loop-specific (limbic only) hypoconnectivity.",
    "effect_size": "N=37 patients vs 29 controls; p<.05 FWE",
    "text_access": "abstract_only",
    "study_system": "human, resting-state fMRI in first-episode schizophrenia",
    "source_cluster_id": "cluster_06",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "We observed significantly decreased FC for the FESZ group relative to the HC group [p < .05, family-wise error (FWE)-corrected] in the limbic loop, but not in the sensorimotor or associative loops, of frontostriatal circuitry.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "To this end, a case-control, cross-sectional study was conducted, wherein resting-state (RS) functional magnetic resonance (fMRI) data were collected from 37 treatment-naïve FESZ patients and 29 healthy control (HC) subjects."
  },
  "section_id": "section_07",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_07_evidence_package.json",
  "effect_size": "N=37 patients vs 29 controls; p<.05 FWE",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-07",
  "source_kind": "review_finding",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:paper-2322405bb214"
  ],
  "source_span": "We observed significantly decreased FC for the FESZ group relative to the HC group [p < .05, family-wise error (FWE)-corrected] in the limbic loop, but not in the sensorimotor or associative loops, of frontostriatal circuitry.",
  "study_system": "human, resting-state fMRI in first-episode schizophrenia",
  "evidence_refs": [
    {
      "ref": "paper:paper-2322405bb214"
    }
  ],
  "section_title": "Parallel Loop Channels: Motor, Limbic, Associative, and Beyond the Classic Three",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "Resting-state fMRI in 37 first-episode schizophrenia patients vs 29 healthy controls with seed-based connectivity to six striatal subregions identified loop-specific (limbic only) hypoconnectivity.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-07",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_07_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}