Details
- scope
- human, resting-state fMRI in first-episode schizophrenia
- section_id
- section_07
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_07_evidence_package.json
- effect_size
- N=37 patients vs 29 controls; p<.05 FWE
- review_repo
- ComputationalReviewLoops
- section_ref
- wiki_page:computationalreviewloops-07
- source_kind
- review_finding
- source_path
- evidence/section_07_evidence_package.json
- source_span
- We observed significantly decreased FC for the FESZ group relative to the HC group [p < .05, family-wise error (FWE)-corrected] in the limbic loop, but not in the sensorimotor or associative loops, of frontostriatal circuitry.
- study_system
- human, resting-state fMRI in first-episode schizophrenia
- section_title
- Parallel Loop Channels: Motor, Limbic, Associative, and Beyond the Classic Three
- evidence_summary
- Resting-state fMRI in 37 first-episode schizophrenia patients vs 29 healthy controls with seed-based connectivity to six striatal subregions identified loop-specific (limbic only) hypoconnectivity.
- review_bundle_ref
- analysis_bundle:ab-d49e54403ef9
- replication_status
- replication_unknown
- review_package_ref
- analysis_bundle:ab-d49e54403ef9
- source_artifact_ref
- wiki_page:computationalreviewloops-07
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_07_evidence_package.json
- commit_sha
- 0632aae8abc141909207fe91f6349b9e36489c3b
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops
Raw fields (5)
- claim_text
In first-episode treatment-naive schizophrenia, resting-state functional connectivity is selectively reduced in the limbic frontostriatal loop—not the sensorimotor or associative loops—linking parallel-loop dysfunction to disorganization symptoms.
- raw_fields
{ "n": 66, "doi": "10.1002/hbm.23879", "claim": "In first-episode treatment-naive schizophrenia, resting-state functional connectivity is selectively reduced in the limbic frontostriatal loop—not the sensorimotor or associative loops—linking parallel-loop dysfunction to disorganization symptoms.", "cite_key": "Lin2017", "evidence": "Resting-state fMRI in 37 first-episode schizophrenia patients vs 29 healthy controls with seed-based connectivity to six striatal subregions identified loop-specific (limbic only) hypoconnectivity.", "effect_size": "N=37 patients vs 29 controls; p<.05 FWE", "text_access": "abstract_only", "study_system": "human, resting-state fMRI in first-episode schizophrenia", "source_cluster_id": "cluster_06", "replication_status": "replication_unknown", "claim_source_sentence": "We observed significantly decreased FC for the FESZ group relative to the HC group [p < .05, family-wise error (FWE)-corrected] in the limbic loop, but not in the sensorimotor or associative loops, of frontostriatal circuitry.", "replication_evidence_dois": [], "effect_size_source_sentence": "To this end, a case-control, cross-sectional study was conducted, wherein resting-state (RS) functional magnetic resonance (fMRI) data were collected from 37 treatment-naïve FESZ patients and 29 healthy control (HC) subjects." }- source_refs
[ "paper:paper-2322405bb214" ]
- evidence_refs
[ { "ref": "paper:paper-2322405bb214" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops" }