Version history

{
  "scope": "mouse S1 layer 4 optogenetics + paired recordings",
  "claim_text": "Xu et al. (2013) found that, in mouse layer 4 somatosensory cortex, SST interneurons target fast-spiking PV cells rather than pyramidal cells, so optogenetic SST silencing decreases L4 principal-neuron firing — demonstrating an SST-mediated disinhibitory motif that breaks the canonical 'VIP-only' disinhibition narrative.",
  "raw_fields": {
    "n": null,
    "doi": "10.1016/j.neuron.2012.11.004",
    "claim": "Xu et al. (2013) found that, in mouse layer 4 somatosensory cortex, SST interneurons target fast-spiking PV cells rather than pyramidal cells, so optogenetic SST silencing decreases L4 principal-neuron firing — demonstrating an SST-mediated disinhibitory motif that breaks the canonical 'VIP-only' disinhibition narrative.",
    "title": null,
    "cite_key": "Xu2013",
    "evidence": "Optogenetic + slice-electrophysiology dissection of SST→FS→L4-PN microcircuit in mouse S1.",
    "effect_size": null,
    "text_access": "abstract_only",
    "study_system": "mouse S1 layer 4 optogenetics + paired recordings",
    "target_section": "section_05",
    "_source_cluster": "cluster_01_molecular_taxonomy",
    "replication_status": "single_study",
    "_source_cluster_index": 69,
    "claim_source_sentence": "Accordingly, optogenetic inhibition of SOM INs in an active cortical network increases the firing of layers 2/3 PCs whereas it decreases the firing of layer 4 principal neurons (PNs)."
  },
  "section_id": "section_11",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_11_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-11-disease-translational",
  "source_kind": "review_finding",
  "source_path": "evidence/section_11_evidence_package.json",
  "source_refs": [
    "paper:paper-92bf23cf430e"
  ],
  "source_span": "Accordingly, optogenetic inhibition of SOM INs in an active cortical network increases the firing of layers 2/3 PCs whereas it decreases the firing of layer 4 principal neurons (PNs).",
  "study_system": "mouse S1 layer 4 optogenetics + paired recordings",
  "evidence_refs": [
    {
      "ref": "paper:paper-92bf23cf430e"
    }
  ],
  "section_title": "Species Differences, Human Relevance, and Disease",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Optogenetic + slice-electrophysiology dissection of SST→FS→L4-PN microcircuit in mouse S1.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "single_study",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-11-disease-translational",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_11_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}