Xu et al. (2013) found that, in mouse layer 4 somatosensory cortex, SST interne…

Xu et al. (2013) found that, in mouse layer 4 somatosensory cortex, SST interneurons target fast-spiking PV cells rather than pyramidal cells, so optogenetic SST silencing decreases L4 principal-neuron firing — demonstrating an SST-mediated disinhibitory motif that breaks the canonical 'VIP-only' disinhibition narrative.

{
  "n": null,
  "doi": "10.1016/j.neuron.2012.11.004",
  "claim": "Xu et al. (2013) found that, in mouse layer 4 somatosensory cortex, SST interneurons target fast-spiking PV cells rather than pyramidal cells, so optogenetic SST silencing decreases L4 principal-neuron firing — demonstrating an SST-mediated disinhibitory motif that breaks the canonical 'VIP-only' disinhibition narrative.",
  "title": null,
  "cite_key": "Xu2013",
  "evidence": "Optogenetic + slice-electrophysiology dissection of SST→FS→L4-PN microcircuit in mouse S1.",
  "effect_size": null,
  "text_access": "abstract_only",
  "study_system": "mouse S1 layer 4 optogenetics + paired recordings",
  "target_section": "section_05",
  "_source_cluster": "cluster_01_molecular_taxonomy",
  "replication_status": "single_study",
  "_source_cluster_index": 69,
  "claim_source_sentence": "Accordingly, optogenetic inhibition of SOM INs in an active cortical network increases the firing of layers 2/3 PCs whereas it decreases the firing of layer 4 principal neurons (PNs)."
}

[
  "paper:paper-92bf23cf430e"
]

[
  {
    "ref": "paper:paper-92bf23cf430e"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}