- claim_text
In cortex-striatum-substantia-nigra organotypic cultures, MSNs show characteristic up-down state activity blocked by the glutamate antagonist CNQX, while fast-spiking interneurons fire at much higher rates and share correlated subthreshold activity, supporting cortically-driven feedforward inhibition.
- raw_fields
{
"n": null,
"doi": "10.1523/jneurosci.18-01-00266.1998",
"claim": "In cortex-striatum-substantia-nigra organotypic cultures, MSNs show characteristic up-down state activity blocked by the glutamate antagonist CNQX, while fast-spiking interneurons fire at much higher rates and share correlated subthreshold activity, supporting cortically-driven feedforward inhibition.",
"cite_key": "Plenz1998",
"evidence": "Triple cortex-striatum-substantia-nigra organotypic cultures (45 ± 4 days) with intracellular recordings of CS, MS and FS neurons.",
"effect_size": "intermittent depolarized periods of 0.5-1 sec duration; cultures grown for 45 ± 4 days",
"text_access": "abstract_only",
"study_system": "rodent organotypic cortex-striatum-SN cultures",
"source_cluster_id": "cluster_02",
"replication_status": "replication_unknown",
"claim_source_sentence": "These up states were completely blocked by the glutamate antagonist CNQX.",
"replication_evidence_dois": [],
"effect_size_source_sentence": "Intracellular spontaneous activity in the cultures consisted of intermittent depolarized periods of 0.5-1 sec duration."
}- source_refs
[
"paper:paper-03f78f82edd1"
]
- evidence_refs
[
{
"ref": "paper:paper-03f78f82edd1"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}