Version history

{
  "scope": "rodent organotypic cortex-striatum-SN cultures",
  "claim_text": "In cortex-striatum-substantia-nigra organotypic cultures, MSNs show characteristic up-down state activity blocked by the glutamate antagonist CNQX, while fast-spiking interneurons fire at much higher rates and share correlated subthreshold activity, supporting cortically-driven feedforward inhibition.",
  "raw_fields": {
    "n": null,
    "doi": "10.1523/jneurosci.18-01-00266.1998",
    "claim": "In cortex-striatum-substantia-nigra organotypic cultures, MSNs show characteristic up-down state activity blocked by the glutamate antagonist CNQX, while fast-spiking interneurons fire at much higher rates and share correlated subthreshold activity, supporting cortically-driven feedforward inhibition.",
    "cite_key": "Plenz1998",
    "evidence": "Triple cortex-striatum-substantia-nigra organotypic cultures (45 ± 4 days) with intracellular recordings of CS, MS and FS neurons.",
    "effect_size": "intermittent depolarized periods of 0.5-1 sec duration; cultures grown for 45 ± 4 days",
    "text_access": "abstract_only",
    "study_system": "rodent organotypic cortex-striatum-SN cultures",
    "source_cluster_id": "cluster_02",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "These up states were completely blocked by the glutamate antagonist CNQX.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Intracellular spontaneous activity in the cultures consisted of intermittent depolarized periods of 0.5-1 sec duration."
  },
  "section_id": "section_02",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_02_evidence_package.json",
  "effect_size": "intermittent depolarized periods of 0.5-1 sec duration; cultures grown for 45 ± 4 days",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-02",
  "source_kind": "review_finding",
  "source_path": "evidence/section_02_evidence_package.json",
  "source_refs": [
    "paper:paper-03f78f82edd1"
  ],
  "source_span": "These up states were completely blocked by the glutamate antagonist CNQX.",
  "study_system": "rodent organotypic cortex-striatum-SN cultures",
  "evidence_refs": [
    {
      "ref": "paper:paper-03f78f82edd1"
    }
  ],
  "section_title": "Classical Anatomy of the Triple Descending Projection",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "Triple cortex-striatum-substantia-nigra organotypic cultures (45 ± 4 days) with intracellular recordings of CS, MS and FS neurons.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-02",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_02_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}