Version history

{
  "scope": "mouse forelimb S1 and M1 cortex with VPL and POm thalamus, optogenetic + retrograde",
  "claim_text": "In mouse forelimb S1, layer-6 corticothalamic (CT) and layer-5B pyramidal-tract (PT) neurons both form recurrent cortico-thalamo-cortical (C-T-C) loops with S1-projecting thalamocortical neurons (in VPL and POm), while adjacent M1 PT neurons form a separate loop with M1-projecting POm cells — establishing recurrent loop organization of mouse C-T-C circuits.",
  "raw_fields": {
    "n": null,
    "doi": "10.1523/jneurosci.2277-19.2020",
    "claim": "In mouse forelimb S1, layer-6 corticothalamic (CT) and layer-5B pyramidal-tract (PT) neurons both form recurrent cortico-thalamo-cortical (C-T-C) loops with S1-projecting thalamocortical neurons (in VPL and POm), while adjacent M1 PT neurons form a separate loop with M1-projecting POm cells — establishing recurrent loop organization of mouse C-T-C circuits.",
    "cite_key": "Guo2020",
    "evidence": "Cell-type-specific anterograde optogenetic excitation combined with single-cell recordings from retrogradely labeled thalamocortical neurons in mouse forelimb S1 and M1.",
    "effect_size": null,
    "text_access": "abstract_only",
    "study_system": "mouse forelimb S1 and M1 cortex with VPL and POm thalamus, optogenetic + retrograde",
    "argument_role": "supporting",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "The CT neurons in S1 synaptically excited S1-projecting thalamocortical (TC) neurons in subregions of both the ventral posterior lateral and posterior (PO) nuclei, forming a pair of recurrent cortico-thalamo-cortical (C-T-C) loops. The PT neurons in S1 also formed a recurrent loop with S1-projecting TC neurons in the same subregion of the PO. The PT neurons in the adjacent primary motor (M1) cortex formed a separate recurrent loop with M1-projecting TC neurons in a nearby subregion of the PO.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_02",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_02_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-02-anatomy-primer",
  "source_kind": "review_finding",
  "source_path": "evidence/section_02_evidence_package.json",
  "source_refs": [
    "paper:paper-7c6266401771"
  ],
  "source_span": "The CT neurons in S1 synaptically excited S1-projecting thalamocortical (TC) neurons in subregions of both the ventral posterior lateral and posterior (PO) nuclei, forming a pair of recurrent cortico-thalamo-cortical (C-T-C) loops. The PT neurons in S1 also formed a recurrent loop with S1-projecting TC neurons in the same subregion of the PO. The PT neurons in the adjacent primary motor (M1) cortex formed a separate...",
  "study_system": "mouse forelimb S1 and M1 cortex with VPL and POm thalamus, optogenetic + retrograde",
  "evidence_refs": [
    {
      "ref": "paper:paper-7c6266401771"
    }
  ],
  "section_title": "2. Mouse-cortex anatomy primer — areal map, layer structure, projection-class nomenclature (IT / PT / CT), tools available for E→E dissection (paired patch, Cre lines, two-photon-targeted patch, optogenetics, EM reconstruction)",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Cell-type-specific anterograde optogenetic excitation combined with single-cell recordings from retrogradely labeled thalamocortical neurons in mouse forelimb S1 and M1.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-02-anatomy-primer",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_02_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}