In mouse forelimb S1, layer-6 corticothalamic (CT) and layer-5B pyramidal-tract…

In mouse forelimb S1, layer-6 corticothalamic (CT) and layer-5B pyramidal-tract (PT) neurons both form recurrent cortico-thalamo-cortical (C-T-C) loops with S1-projecting thalamocortical neurons (in VPL and POm), while adjacent M1 PT neurons form a separate loop with M1-projecting POm cells — establishing recurrent loop organization of mouse C-T-C circuits.

{
  "n": null,
  "doi": "10.1523/jneurosci.2277-19.2020",
  "claim": "In mouse forelimb S1, layer-6 corticothalamic (CT) and layer-5B pyramidal-tract (PT) neurons both form recurrent cortico-thalamo-cortical (C-T-C) loops with S1-projecting thalamocortical neurons (in VPL and POm), while adjacent M1 PT neurons form a separate loop with M1-projecting POm cells — establishing recurrent loop organization of mouse C-T-C circuits.",
  "cite_key": "Guo2020",
  "evidence": "Cell-type-specific anterograde optogenetic excitation combined with single-cell recordings from retrogradely labeled thalamocortical neurons in mouse forelimb S1 and M1.",
  "effect_size": null,
  "text_access": "abstract_only",
  "study_system": "mouse forelimb S1 and M1 cortex with VPL and POm thalamus, optogenetic + retrograde",
  "argument_role": "supporting",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "The CT neurons in S1 synaptically excited S1-projecting thalamocortical (TC) neurons in subregions of both the ventral posterior lateral and posterior (PO) nuclei, forming a pair of recurrent cortico-thalamo-cortical (C-T-C) loops. The PT neurons in S1 also formed a recurrent loop with S1-projecting TC neurons in the same subregion of the PO. The PT neurons in the adjacent primary motor (M1) cortex formed a separate recurrent loop with M1-projecting TC neurons in a nearby subregion of the PO.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

[
  "paper:paper-7c6266401771"
]

The CT neurons in S1 synaptically excited S1-projecting thalamocortical (TC) neurons in subregions of both the ventral posterior lateral and posterior (PO) nuclei, forming a pair of recurrent cortico-thalamo-cortical (C-T-C) loops. The PT neurons in S1 also formed a recurrent loop with S1-projecting TC neurons in the same subregion of the PO. The PT neurons in the adjacent primary motor (M1) cortex formed a separate...

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    "ref": "paper:paper-7c6266401771"
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    "Local review repositories are read-only inputs.",
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