Details
- scope
- Mouse primary visual cortex L2/3 excitatory neurons (in vivo deprivation + slice recording)
- claim_text
- Input-specific metaplasticity in mouse V1 — rapid reduction of excitatory synaptic strength at intracortical inputs to L2/3 neurons upon light re-exposure after deprivation — requires NMDA receptors, mGluR5, and Homer1a.
- section_id
- section_12
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_12_evidence_package.json
- review_repo
- ComputationalReviewRecurrence
- section_ref
- wiki_page:computationalreviewrecurrence-12-plasticity
- source_kind
- review_finding
- source_path
- evidence/section_12_evidence_package.json
- source_span
- Here, we report that this form of plasticity is specific to intracortical inputs to V1 L2/3 neurons and depends on the activity of NMDA receptors (NMDARs) and group I metabotropic glutamate receptor 5 (mGluR5).
- study_system
- Mouse primary visual cortex L2/3 excitatory neurons (in vivo deprivation + slice recording)
- section_title
- 12. Plasticity at E→E synapses in mouse — Hebbian, STDP, behavioural-time-scale plasticity; how plasticity shapes the recurrent matrix during learning
- evidence_summary
- Reexposure to light after deprivation triggers rapid weakening of excitatory synapses specifically at intracortical inputs to V1 L2/3 neurons; this depends on NMDAR/mGluR5 and on Homer1a-mGluR5 interaction.
- review_bundle_ref
- analysis_bundle:ab-d9c479db9be9
- replication_status
- replication_unknown
- review_package_ref
- analysis_bundle:ab-d9c479db9be9
- source_artifact_ref
- wiki_page:computationalreviewrecurrence-12-plasticity
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_12_evidence_package.json
- commit_sha
- 79ce062d54a924ce05953ec90aa9d26044d2b48f
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence
Raw fields (4)
- raw_fields
{ "n": 0, "doi": "10.1016/j.neuron.2019.08.017", "claim": "Input-specific metaplasticity in mouse V1 — rapid reduction of excitatory synaptic strength at intracortical inputs to L2/3 neurons upon light re-exposure after deprivation — requires NMDA receptors, mGluR5, and Homer1a.", "cite_key": "Chokshi2019a", "evidence": "Reexposure to light after deprivation triggers rapid weakening of excitatory synapses specifically at intracortical inputs to V1 L2/3 neurons; this depends on NMDAR/mGluR5 and on Homer1a-mGluR5 interaction.", "effect_size": null, "text_access": "abstract_only", "study_system": "Mouse primary visual cortex L2/3 excitatory neurons (in vivo deprivation + slice recording)", "argument_role": "supporting", "replication_status": "replication_unknown", "claim_source_sentence": "Here, we report that this form of plasticity is specific to intracortical inputs to V1 L2/3 neurons and depends on the activity of NMDA receptors (NMDARs) and group I metabotropic glutamate receptor 5 (mGluR5).", "source_provenance_status": "non_substring_match", "replication_evidence_dois": [], "effect_size_source_sentence": null }- source_refs
[ "paper:paper-f6de43937da2" ]
- evidence_refs
[ { "ref": "paper:paper-f6de43937da2" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence" }