Version history

{
  "scope": "mouse (dorsal striatum PV translatome)",
  "claim_text": "RiboTag profiling of dorsal-striatum parvalbumin interneurons in Pvalb-Cre mice identifies >2,700 enriched transcripts and a distinct molecular signature relative to nucleus-accumbens PV interneurons, with prominent expression of perineuronal-net markers, cell-adhesion molecules and synaptic-organization genes.",
  "raw_fields": {
    "n": null,
    "doi": "10.3389/fncel.2025.1648461",
    "claim": "RiboTag profiling of dorsal-striatum parvalbumin interneurons in Pvalb-Cre mice identifies >2,700 enriched transcripts and a distinct molecular signature relative to nucleus-accumbens PV interneurons, with prominent expression of perineuronal-net markers, cell-adhesion molecules and synaptic-organization genes.",
    "cite_key": "Naon2025",
    "evidence": "Ribotag immunoprecipitation + RNAseq of dorsal-striatum PV interneurons across baseline, d-amphetamine, and operant-reward conditions in Pvalb-Cre mice.",
    "effect_size": ">2,700 transcripts enriched FC>1.5; >1,000 / 100 genes regulated by reward type",
    "text_access": "abstract_only",
    "study_system": "mouse (dorsal striatum PV translatome)",
    "source_cluster_id": "cluster_03",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "Using the Ribotag approach in Pvalb-Cre mice, we profiled the translatome of DS PV interneurons and identified over 2,700 transcripts significantly enriched (fold-change > 1.5) in this population.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Furthermore, RNAseq analysis of mice subjected to an operant behavior paradigm with two types of food reward (high-palatable diet or standard chow) identified over 1,000 and 100 genes enriched in DS PV neurons from standard and high-palatable masters, respectively."
  },
  "section_id": "section_03",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_03_evidence_package.json",
  "effect_size": ">2,700 transcripts enriched FC>1.5; >1,000 / 100 genes regulated by reward type",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-03",
  "source_kind": "review_finding",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:paper-15ca88723842"
  ],
  "source_span": "Using the Ribotag approach in Pvalb-Cre mice, we profiled the translatome of DS PV interneurons and identified over 2,700 transcripts significantly enriched (fold-change > 1.5) in this population.",
  "study_system": "mouse (dorsal striatum PV translatome)",
  "evidence_refs": [
    {
      "ref": "paper:paper-15ca88723842"
    }
  ],
  "section_title": "The Cortico-Striatal Interface: Topography, Cell Types, and Input Convergence",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "Ribotag immunoprecipitation + RNAseq of dorsal-striatum PV interneurons across baseline, d-amphetamine, and operant-reward conditions in Pvalb-Cre mice.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-03",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_03_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}