Details
- scope
- mouse (dorsal striatum PV translatome)
- section_id
- section_03
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_03_evidence_package.json
- effect_size
- >2,700 transcripts enriched FC>1.5; >1,000 / 100 genes regulated by reward type
- review_repo
- ComputationalReviewLoops
- section_ref
- wiki_page:computationalreviewloops-03
- source_kind
- review_finding
- source_path
- evidence/section_03_evidence_package.json
- source_span
- Using the Ribotag approach in Pvalb-Cre mice, we profiled the translatome of DS PV interneurons and identified over 2,700 transcripts significantly enriched (fold-change > 1.5) in this population.
- study_system
- mouse (dorsal striatum PV translatome)
- section_title
- The Cortico-Striatal Interface: Topography, Cell Types, and Input Convergence
- evidence_summary
- Ribotag immunoprecipitation + RNAseq of dorsal-striatum PV interneurons across baseline, d-amphetamine, and operant-reward conditions in Pvalb-Cre mice.
- review_bundle_ref
- analysis_bundle:ab-d49e54403ef9
- replication_status
- replication_unknown
- review_package_ref
- analysis_bundle:ab-d49e54403ef9
- source_artifact_ref
- wiki_page:computationalreviewloops-03
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_03_evidence_package.json
- commit_sha
- 0632aae8abc141909207fe91f6349b9e36489c3b
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops
Raw fields (5)
- claim_text
RiboTag profiling of dorsal-striatum parvalbumin interneurons in Pvalb-Cre mice identifies >2,700 enriched transcripts and a distinct molecular signature relative to nucleus-accumbens PV interneurons, with prominent expression of perineuronal-net markers, cell-adhesion molecules and synaptic-organization genes.
- raw_fields
{ "n": null, "doi": "10.3389/fncel.2025.1648461", "claim": "RiboTag profiling of dorsal-striatum parvalbumin interneurons in Pvalb-Cre mice identifies >2,700 enriched transcripts and a distinct molecular signature relative to nucleus-accumbens PV interneurons, with prominent expression of perineuronal-net markers, cell-adhesion molecules and synaptic-organization genes.", "cite_key": "Naon2025", "evidence": "Ribotag immunoprecipitation + RNAseq of dorsal-striatum PV interneurons across baseline, d-amphetamine, and operant-reward conditions in Pvalb-Cre mice.", "effect_size": ">2,700 transcripts enriched FC>1.5; >1,000 / 100 genes regulated by reward type", "text_access": "abstract_only", "study_system": "mouse (dorsal striatum PV translatome)", "source_cluster_id": "cluster_03", "replication_status": "replication_unknown", "claim_source_sentence": "Using the Ribotag approach in Pvalb-Cre mice, we profiled the translatome of DS PV interneurons and identified over 2,700 transcripts significantly enriched (fold-change > 1.5) in this population.", "replication_evidence_dois": [], "effect_size_source_sentence": "Furthermore, RNAseq analysis of mice subjected to an operant behavior paradigm with two types of food reward (high-palatable diet or standard chow) identified over 1,000 and 100 genes enriched in DS PV neurons from standard and high-palatable masters, respectively." }- source_refs
[ "paper:paper-15ca88723842" ]
- evidence_refs
[ { "ref": "paper:paper-15ca88723842" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops" }