Version history

{
  "scope": "Mouse V1; feedback-axon manipulation + RF measurement.",
  "claim_text": "In mouse primary visual cortex, top-down feedback projections from higher visual areas generate a second, larger non-classical receptive field on V1 excitatory neurons via L5 apical-tuft input — providing direct evidence that cortico-cortical feedback contributes a defined extra-classical RF rather than merely modulating ffRF.",
  "raw_fields": {
    "n": null,
    "doi": "10.1038/s41586-020-2319-4",
    "claim": "In mouse primary visual cortex, top-down feedback projections from higher visual areas generate a second, larger non-classical receptive field on V1 excitatory neurons via L5 apical-tuft input — providing direct evidence that cortico-cortical feedback contributes a defined extra-classical RF rather than merely modulating ffRF.",
    "cite_key": "Keller2020b",
    "evidence": "Two-photon optogenetic and pharmacological manipulation of higher-area feedback projections + V1 cell-attached recording; surround stimulus testing.",
    "effect_size": "Feedback projections to V1 generate a distinct second (extraclassical) receptive field on excitatory neurons.",
    "text_access": "abstract_only",
    "study_system": "Mouse V1; feedback-axon manipulation + RF measurement.",
    "argument_role": "supporting",
    "replication_status": "not_yet",
    "claim_source_sentence": "we show that feedback projections onto excitatory neurons in the mouse primary visual cortex generate a second receptive field that is driven by stimuli outside the ffRF.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Here we show that feedback projections onto excitatory neurons in the mouse primary visual cortex generate a second receptive field that is driven by stimuli outside the ffRF."
  },
  "section_id": "section_08",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_08_evidence_package.json",
  "effect_size": "Feedback projections to V1 generate a distinct second (extraclassical) receptive field on excitatory neurons.",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-08-cross-areal",
  "source_kind": "review_finding",
  "source_path": "evidence/section_08_evidence_package.json",
  "source_refs": [
    "paper:paper-e69f1cba3510"
  ],
  "source_span": "we show that feedback projections onto excitatory neurons in the mouse primary visual cortex generate a second receptive field that is driven by stimuli outside the ffRF.",
  "study_system": "Mouse V1; feedback-axon manipulation + RF measurement.",
  "evidence_refs": [
    {
      "ref": "paper:paper-e69f1cba3510"
    }
  ],
  "section_title": "8. Cross-areal mouse cortico-cortical excitatory connectivity — hierarchical feedforward and feedback as recurrent loops at the network level; Allen Mouse Connectivity Atlas anchored views",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Two-photon optogenetic and pharmacological manipulation of higher-area feedback projections + V1 cell-attached recording; surround stimulus testing.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "not_yet",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-08-cross-areal",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_08_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}