Version history

{
  "scope": "awake actively-sensing mouse barrel cortex L2/3 → L5",
  "claim_text": "In awake mouse barrel cortex during active sensing, optogenetic activation of L2/3 predominantly suppresses spontaneous activity in L5, while deactivation of L2/3 facilitates touch responses in L5 — the descending L2/3→L5 microcircuit functions through net inhibition (involving SST interneurons) rather than purely feedforward excitation, expanding stimulus-selectivity and dynamic range of L5 output.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1523/jneurosci.1459-18.2018",
    "claim": "In awake mouse barrel cortex during active sensing, optogenetic activation of L2/3 predominantly suppresses spontaneous activity in L5, while deactivation of L2/3 facilitates touch responses in L5 — the descending L2/3→L5 microcircuit functions through net inhibition (involving SST interneurons) rather than purely feedforward excitation, expanding stimulus-selectivity and dynamic range of L5 output.",
    "cite_key": "Pluta2019",
    "evidence": "Cell-type-specific optogenetic manipulation of L2/3 excitatory and L5/SST inhibitory neurons during head-fixed whisker behavior with simultaneous L5 electrophysiology in mouse barrel cortex.",
    "effect_size": "qualitative — net suppressive L2/3→L5 functional effect; SST-dependent",
    "text_access": "abstract_only",
    "study_system": "awake actively-sensing mouse barrel cortex L2/3 → L5",
    "argument_role": "supporting",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "activating L2/3 predominantly suppressed spontaneous activity in L5, whereas deactivating L2/3 mainly facilitated touch responses in L5. Somatostatin interneurons are likely important to this suppression because their optogenetic deactivation significantly altered the functional impact of L2/3 onto L5",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [
      "10.1038/nn.4123"
    ],
    "effect_size_source_sentence": "activating L2/3 predominantly suppressed spontaneous activity in L5"
  },
  "section_id": "section_07",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json",
  "effect_size": "qualitative — net suppressive L2/3→L5 functional effect; SST-dependent",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
  "source_kind": "review_finding",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:paper-ec77beb36424"
  ],
  "source_span": "activating L2/3 predominantly suppressed spontaneous activity in L5, whereas deactivating L2/3 mainly facilitated touch responses in L5. Somatostatin interneurons are likely important to this suppression because their optogenetic deactivation significantly altered the functional impact of L2/3 onto L5",
  "study_system": "awake actively-sensing mouse barrel cortex L2/3 → L5",
  "evidence_refs": [
    {
      "ref": "paper:paper-ec77beb36424"
    }
  ],
  "section_title": "7. Cell-type-specific E→E motifs in mouse — IT vs PT vs CT pyramidal projection classes; L5 thick-tufted recurrence; Patch-seq and Allen mouse-cortex taxonomy intersections; transcriptomic-type-specific connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Cell-type-specific optogenetic manipulation of L2/3 excitatory and L5/SST inhibitory neurons during head-fixed whisker behavior with simultaneous L5 electrophysiology in mouse barrel cortex.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}