In awake mouse barrel cortex during active sensing, optogenetic activation of L…

In awake mouse barrel cortex during active sensing, optogenetic activation of L2/3 predominantly suppresses spontaneous activity in L5, while deactivation of L2/3 facilitates touch responses in L5 — the descending L2/3→L5 microcircuit functions through net inhibition (involving SST interneurons) rather than purely feedforward excitation, expanding stimulus-selectivity and dynamic range of L5 output.

{
  "n": 0,
  "doi": "10.1523/jneurosci.1459-18.2018",
  "claim": "In awake mouse barrel cortex during active sensing, optogenetic activation of L2/3 predominantly suppresses spontaneous activity in L5, while deactivation of L2/3 facilitates touch responses in L5 — the descending L2/3→L5 microcircuit functions through net inhibition (involving SST interneurons) rather than purely feedforward excitation, expanding stimulus-selectivity and dynamic range of L5 output.",
  "cite_key": "Pluta2019",
  "evidence": "Cell-type-specific optogenetic manipulation of L2/3 excitatory and L5/SST inhibitory neurons during head-fixed whisker behavior with simultaneous L5 electrophysiology in mouse barrel cortex.",
  "effect_size": "qualitative — net suppressive L2/3→L5 functional effect; SST-dependent",
  "text_access": "abstract_only",
  "study_system": "awake actively-sensing mouse barrel cortex L2/3 → L5",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "activating L2/3 predominantly suppressed spontaneous activity in L5, whereas deactivating L2/3 mainly facilitated touch responses in L5. Somatostatin interneurons are likely important to this suppression because their optogenetic deactivation significantly altered the functional impact of L2/3 onto L5",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.1038/nn.4123"
  ],
  "effect_size_source_sentence": "activating L2/3 predominantly suppressed spontaneous activity in L5"
}

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  "paper:paper-ec77beb36424"
]

activating L2/3 predominantly suppressed spontaneous activity in L5, whereas deactivating L2/3 mainly facilitated touch responses in L5. Somatostatin interneurons are likely important to this suppression because their optogenetic deactivation significantly altered the functional impact of L2/3 onto L5

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