Version history

{
  "scope": "mouse primary motor cortex (M1) multi-omics atlas",
  "claim_text": "The BICCN multi-omics cell atlas of mouse primary motor cortex (M1), integrating transcriptomes and epigenomes of >500,000 cells, defines ≥56 highly replicable neuronal types and reveals an excitatory population resembling sensory-cortex layer 4 neurons within M1.",
  "raw_fields": {
    "n": 500000,
    "doi": "10.1038/s41586-021-03500-8",
    "claim": "The BICCN multi-omics cell atlas of mouse primary motor cortex (M1), integrating transcriptomes and epigenomes of >500,000 cells, defines ≥56 highly replicable neuronal types and reveals an excitatory population resembling sensory-cortex layer 4 neurons within M1.",
    "cite_key": "Yao2021b",
    "evidence": "Integrated single-cell/single-nucleus RNA-seq, ATAC-seq, MERFISH and DNA-methylation profiling of >500,000 cells from mouse primary motor cortex with cross-modal computational integration.",
    "effect_size": ">56 replicable cell types in mouse M1; one excitatory L4-like type identified",
    "text_access": "fulltext",
    "study_system": "mouse primary motor cortex (M1) multi-omics atlas",
    "argument_role": "supporting",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "The resulting reference atlas—containing over 56 neuronal cell types that are highly replicable across analysis methods, sequencing technologies and modalities—is a comprehensive molecular and genomic account of the diverse neuronal and non-neuronal cell types in the mouse primary motor cortex. The atlas includes a population of excitatory neurons that resemble pyramidal cells in layer 4 in other cortical regions",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [
      "10.1038/s41586-021-03950-0",
      "10.7554/eLife.05422"
    ],
    "effect_size_source_sentence": "containing over 56 neuronal cell types that are highly replicable"
  },
  "section_id": "section_07",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json",
  "effect_size": ">56 replicable cell types in mouse M1; one excitatory L4-like type identified",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
  "source_kind": "review_finding",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:paper-0c694a60c289"
  ],
  "source_span": "The resulting reference atlas—containing over 56 neuronal cell types that are highly replicable across analysis methods, sequencing technologies and modalities—is a comprehensive molecular and genomic account of the diverse neuronal and non-neuronal cell types in the mouse primary motor cortex. The atlas includes a population of excitatory neurons that resemble pyramidal cells in layer 4 in other cortical regions",
  "study_system": "mouse primary motor cortex (M1) multi-omics atlas",
  "evidence_refs": [
    {
      "ref": "paper:paper-0c694a60c289"
    }
  ],
  "section_title": "7. Cell-type-specific E→E motifs in mouse — IT vs PT vs CT pyramidal projection classes; L5 thick-tufted recurrence; Patch-seq and Allen mouse-cortex taxonomy intersections; transcriptomic-type-specific connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Integrated single-cell/single-nucleus RNA-seq, ATAC-seq, MERFISH and DNA-methylation profiling of >500,000 cells from mouse primary motor cortex with cross-modal computational integration.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}