The BICCN multi-omics cell atlas of mouse primary motor cortex (M1), integratin…

The BICCN multi-omics cell atlas of mouse primary motor cortex (M1), integrating transcriptomes and epigenomes of >500,000 cells, defines ≥56 highly replicable neuronal types and reveals an excitatory population resembling sensory-cortex layer 4 neurons within M1.

{
  "n": 500000,
  "doi": "10.1038/s41586-021-03500-8",
  "claim": "The BICCN multi-omics cell atlas of mouse primary motor cortex (M1), integrating transcriptomes and epigenomes of >500,000 cells, defines ≥56 highly replicable neuronal types and reveals an excitatory population resembling sensory-cortex layer 4 neurons within M1.",
  "cite_key": "Yao2021b",
  "evidence": "Integrated single-cell/single-nucleus RNA-seq, ATAC-seq, MERFISH and DNA-methylation profiling of >500,000 cells from mouse primary motor cortex with cross-modal computational integration.",
  "effect_size": ">56 replicable cell types in mouse M1; one excitatory L4-like type identified",
  "text_access": "fulltext",
  "study_system": "mouse primary motor cortex (M1) multi-omics atlas",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "The resulting reference atlas—containing over 56 neuronal cell types that are highly replicable across analysis methods, sequencing technologies and modalities—is a comprehensive molecular and genomic account of the diverse neuronal and non-neuronal cell types in the mouse primary motor cortex. The atlas includes a population of excitatory neurons that resemble pyramidal cells in layer 4 in other cortical regions",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [
    "10.1038/s41586-021-03950-0",
    "10.7554/eLife.05422"
  ],
  "effect_size_source_sentence": "containing over 56 neuronal cell types that are highly replicable"
}

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  "paper:paper-0c694a60c289"
]

The resulting reference atlas—containing over 56 neuronal cell types that are highly replicable across analysis methods, sequencing technologies and modalities—is a comprehensive molecular and genomic account of the diverse neuronal and non-neuronal cell types in the mouse primary motor cortex. The atlas includes a population of excitatory neurons that resemble pyramidal cells in layer 4 in other cortical regions

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