Version history

{
  "scope": "mouse visual cortex layer 6, Ntsr1-Cre GN220 line",
  "claim_text": "The Ntsr1-Cre GN220 line labels approximately 90% of layer 6 corticothalamic neurons, indicating incomplete penetrance rather than coverage of all CT cells.",
  "raw_fields": {
    "n": null,
    "doi": "10.1002/cne.24323",
    "claim": "The Ntsr1-Cre GN220 line labels approximately 90% of layer 6 corticothalamic neurons, indicating incomplete penetrance rather than coverage of all CT cells.",
    "cite_key": "Sundberg2018",
    "evidence": "Quantification of overlap between Cre expression and CT-neuron identity using retrograde tracing and immunohistochemistry.",
    "effect_size": "~90% penetrance",
    "text_access": "abstract_only",
    "study_system": "mouse visual cortex layer 6, Ntsr1-Cre GN220 line",
    "argument_role": "supporting",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "We conclude that Cre-expression is limited to a specific type of pyramidal neuron: CT. However, it appears as not all CT neurons are Cre-expressing; there are indications that the penetrance of the gene is about 90%. We demonstrate the utility of assigning a specific identity to individual neurons by determining that the CT neurons are potently modulated by acetylcholine acting on both nicotinic and muscarinic acetylcholine receptors.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "We conclude that Cre-expression is limited to a specific type of pyramidal neuron: CT. However, it appears as not all CT neurons are Cre-expressing; there are indications that the penetrance of the gene is about 90%. We demonstrate the utility of assigning a specific identity to individual neurons by determining that the CT neurons are potently modulated by acetylcholine acting on both nicotinic and muscarinic acetylcholine receptors."
  },
  "section_id": "section_01",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_01_evidence_package.json",
  "effect_size": "~90% penetrance",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-01-introduction",
  "source_kind": "review_finding",
  "source_path": "evidence/section_01_evidence_package.json",
  "source_refs": [
    "paper:paper-6dee72af1f39"
  ],
  "source_span": "We conclude that Cre-expression is limited to a specific type of pyramidal neuron: CT. However, it appears as not all CT neurons are Cre-expressing; there are indications that the penetrance of the gene is about 90%. We demonstrate the utility of assigning a specific identity to individual neurons by determining that the CT neurons are potently modulated by acetylcholine acting on both nicotinic and muscarinic acety...",
  "study_system": "mouse visual cortex layer 6, Ntsr1-Cre GN220 line",
  "evidence_refs": [
    {
      "ref": "paper:paper-6dee72af1f39"
    }
  ],
  "section_title": "1. Introduction — what \"excitatory recurrence\" means operationally in mouse cortex, and why isolating it from inhibition and from clinical framings is a defensible analytic move for basic-research synthesis",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Quantification of overlap between Cre expression and CT-neuron identity using retrograde tracing and immunohistochemistry.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-01-introduction",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_01_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}