- raw_fields
{
"n": null,
"doi": "10.1002/cne.24323",
"claim": "The Ntsr1-Cre GN220 line labels approximately 90% of layer 6 corticothalamic neurons, indicating incomplete penetrance rather than coverage of all CT cells.",
"cite_key": "Sundberg2018",
"evidence": "Quantification of overlap between Cre expression and CT-neuron identity using retrograde tracing and immunohistochemistry.",
"effect_size": "~90% penetrance",
"text_access": "abstract_only",
"study_system": "mouse visual cortex layer 6, Ntsr1-Cre GN220 line",
"argument_role": "supporting",
"replication_status": "replication_unknown",
"claim_source_sentence": "We conclude that Cre-expression is limited to a specific type of pyramidal neuron: CT. However, it appears as not all CT neurons are Cre-expressing; there are indications that the penetrance of the gene is about 90%. We demonstrate the utility of assigning a specific identity to individual neurons by determining that the CT neurons are potently modulated by acetylcholine acting on both nicotinic and muscarinic acetylcholine receptors.",
"source_provenance_status": "non_substring_match",
"replication_evidence_dois": [],
"effect_size_source_sentence": "We conclude that Cre-expression is limited to a specific type of pyramidal neuron: CT. However, it appears as not all CT neurons are Cre-expressing; there are indications that the penetrance of the gene is about 90%. We demonstrate the utility of assigning a specific identity to individual neurons by determining that the CT neurons are potently modulated by acetylcholine acting on both nicotinic and muscarinic acetylcholine receptors."
}- source_refs
[
"paper:paper-6dee72af1f39"
]
- source_span
We conclude that Cre-expression is limited to a specific type of pyramidal neuron: CT. However, it appears as not all CT neurons are Cre-expressing; there are indications that the penetrance of the gene is about 90%. We demonstrate the utility of assigning a specific identity to individual neurons by determining that the CT neurons are potently modulated by acetylcholine acting on both nicotinic and muscarinic acety...
- evidence_refs
[
{
"ref": "paper:paper-6dee72af1f39"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}