Version history

{
  "scope": "vip-interneurons",
  "claim_text": "In Scn1a+/- Dravet mice, VIP-IN activation during quiet-to-running transitions is diminished; optogenetic VIP activation rescues pyramidal-cell activity during locomotion",
  "raw_fields": {
    "n": null,
    "doi": "10.1016/j.celrep.2023.112628",
    "pmid": "37310860",
    "tags": [
      "arousal"
    ],
    "year": "2023",
    "claim": "In Scn1a+/- Dravet mice, VIP-IN activation during quiet-to-running transitions is diminished; optogenetic VIP activation rescues pyramidal-cell activity during locomotion",
    "pmcid": "PMC10592464",
    "title": "VIP interneuron impairment promotes in vivo circuit dysfunction and autism-related behaviors in Dravet syndrome.",
    "journal": "",
    "citation": "Goff KM, Liebergall SR, Jiang E, Somarowthu A, Goldberg EM.",
    "cite_key": "Goff2023",
    "effect_size": null,
    "text_access": "fulltext",
    "citedByCount": 35,
    "isOpenAccess": "Y",
    "evidence_type": "mechanism",
    "linked_topics": [
      "arousal"
    ],
    "_source_cluster": "cluster_07_in_vivo_function",
    "relevance_score": 0.7,
    "replication_status": null,
    "_source_cluster_index": 30,
    "claim_source_sentence": "VIP-IN and pyramidal neuron activation during behavioral transition from quiet wakefulness to active running is diminished in Scn1a<sup>+/-</sup> mice, and optogenetic activation of VIP-INs restores pyramidal neuron activity to WT levels during locomotion."
  },
  "section_id": "section_13",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_13_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-13-conclusion",
  "source_kind": "review_finding",
  "source_path": "evidence/section_13_evidence_package.json",
  "source_refs": [
    "paper:paper-88bb0025c2ee"
  ],
  "source_span": "VIP-IN and pyramidal neuron activation during behavioral transition from quiet wakefulness to active running is diminished in Scn1a<sup>+/-</sup> mice, and optogenetic activation of VIP-INs restores pyramidal neuron activity to WT levels during locomotion.",
  "study_system": null,
  "evidence_refs": [
    {
      "ref": "paper:paper-88bb0025c2ee"
    }
  ],
  "section_title": "Synthesis and Conclusion: Reassessing the Canonical VIP Disinhibitor",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": null,
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "unevaluated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-13-conclusion",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_13_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}