In Scn1a+/- Dravet mice, VIP-IN activation during quiet-to-running transitions…

Details

scope: vip-interneurons
claim_text: In Scn1a+/- Dravet mice, VIP-IN activation during quiet-to-running transitions is diminished; optogenetic VIP activation rescues pyramidal-cell activity during locomotion
section_id: section_13
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_13_evidence_package.json
review_repo: ComputationalReviewVIP
section_ref: wiki_page:computationalreviewvip-13-conclusion
source_kind: review_finding
source_path: evidence/section_13_evidence_package.json
section_title: Synthesis and Conclusion: Reassessing the Canonical VIP Disinhibitor
review_bundle_ref: analysis_bundle:ab-2ce40c33e827
replication_status: unevaluated
review_package_ref: analysis_bundle:ab-2ce40c33e827
source_artifact_ref: wiki_page:computationalreviewvip-13-conclusion
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_13_evidence_package.json
commit_sha: 95e761177f7d2ec565983d3307c14ec238f9677c
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewVIP

Raw fields (5)

raw_fields

{
  "n": null,
  "doi": "10.1016/j.celrep.2023.112628",
  "pmid": "37310860",
  "tags": [
    "arousal"
  ],
  "year": "2023",
  "claim": "In Scn1a+/- Dravet mice, VIP-IN activation during quiet-to-running transitions is diminished; optogenetic VIP activation rescues pyramidal-cell activity during locomotion",
  "pmcid": "PMC10592464",
  "title": "VIP interneuron impairment promotes in vivo circuit dysfunction and autism-related behaviors in Dravet syndrome.",
  "journal": "",
  "citation": "Goff KM, Liebergall SR, Jiang E, Somarowthu A, Goldberg EM.",
  "cite_key": "Goff2023",
  "effect_size": null,
  "text_access": "fulltext",
  "citedByCount": 35,
  "isOpenAccess": "Y",
  "evidence_type": "mechanism",
  "linked_topics": [
    "arousal"
  ],
  "_source_cluster": "cluster_07_in_vivo_function",
  "relevance_score": 0.7,
  "replication_status": null,
  "_source_cluster_index": 30,
  "claim_source_sentence": "VIP-IN and pyramidal neuron activation during behavioral transition from quiet wakefulness to active running is diminished in Scn1a<sup>+/-</sup> mice, and optogenetic activation of VIP-INs restores pyramidal neuron activity to WT levels during locomotion."
}

source_refs

[
  "paper:paper-88bb0025c2ee"
]

source_span

VIP-IN and pyramidal neuron activation during behavioral transition from quiet wakefulness to active running is diminished in Scn1a<sup>+/-</sup> mice, and optogenetic activation of VIP-INs restores pyramidal neuron activity to WT levels during locomotion.

evidence_refs

[
  {
    "ref": "paper:paper-88bb0025c2ee"
  }
]

source_policy

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In Scn1a+/- Dravet mice, VIP-IN activation during quiet-to-running transitions…

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