Version history

{
  "scope": "mouse primary visual cortex (V1) engram",
  "claim_text": "In mouse V1, visually-cued engram neurons tagged by TRAP are selectively reactivated during post-conditioning sleep, and optogenetic inhibition of these neurons during sleep disrupts consolidation of the fear memory.",
  "raw_fields": {
    "n": null,
    "doi": "10.1038/s41467-021-21471-2",
    "claim": "In mouse V1, visually-cued engram neurons tagged by TRAP are selectively reactivated during post-conditioning sleep, and optogenetic inhibition of these neurons during sleep disrupts consolidation of the fear memory.",
    "cite_key": "Clawson2021",
    "evidence": "TRAP-tagged V1 engram + optogenetic inhibition during sleep + behavioral fear assays in mice.",
    "effect_size": null,
    "text_access": "abstract_only",
    "study_system": "mouse primary visual cortex (V1) engram",
    "argument_role": "supporting",
    "replication_status": "within_lab_replication",
    "claim_source_sentence": "Optogenetic inhibition of the engram population during post-conditioning sleep disrupts consolidation of fear memory.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [
      "10.1126/sciadv.adu9800",
      "10.1073/pnas.1818432116"
    ],
    "effect_size_source_sentence": null
  },
  "section_id": "section_11",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_11_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-11-pattern-completion",
  "source_kind": "review_finding",
  "source_path": "evidence/section_11_evidence_package.json",
  "source_refs": [
    "paper:paper-db04b23b3693"
  ],
  "source_span": "Optogenetic inhibition of the engram population during post-conditioning sleep disrupts consolidation of fear memory.",
  "study_system": "mouse primary visual cortex (V1) engram",
  "evidence_refs": [
    {
      "ref": "paper:paper-db04b23b3693"
    }
  ],
  "section_title": "11. Physiological signature III — pattern completion, replay, and sequence generation as recurrent-circuit read-outs in mouse cortex",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "TRAP-tagged V1 engram + optogenetic inhibition during sleep + behavioral fear assays in mice.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "within_lab_replication",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-11-pattern-completion",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_11_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}