- claim_text
VIP and SST interneurons in mouse V1 have complementary contrast tuning: VIP neurons respond strongly to low-contrast front-to-back optic flow congruent with self-motion but are suppressed by other directions and high contrast, while SST cells show the opposite preference — VIP-SST mutual antagonism regulates cortical gain to enhance sensitivity to specific weak stimuli without compromising network stability.
- raw_fields
{
"n": null,
"doi": "10.7554/elife.55130",
"claim": "VIP and SST interneurons in mouse V1 have complementary contrast tuning: VIP neurons respond strongly to low-contrast front-to-back optic flow congruent with self-motion but are suppressed by other directions and high contrast, while SST cells show the opposite preference — VIP-SST mutual antagonism regulates cortical gain to enhance sensitivity to specific weak stimuli without compromising network stability.",
"title": null,
"cite_key": "Millman2020",
"evidence": "in vivo two-photon Ca2+ imaging during visual stimulation + locomotion in mouse V1; computational network model",
"effect_size": "qualitative — VIP/SST contrast tuning are mirror-image complementary; gain modulation through mutual antagonism",
"text_access": "fulltext",
"study_system": "mouse V1 in vivo 2-photon imaging during locomotion",
"_source_cluster": "cluster_04_intrinsic_electrophysiology",
"replication_status": "replicated",
"_source_cluster_index": 58,
"claim_source_sentence": "VIP and SST neurons have complementary contrast tuning.",
"replication_evidence_dois": [
"10.1038/s41586-022-04915-7",
"10.1038/nn.3446"
],
"effect_size_source_sentence": "Network modeling indicates that VIP-SST mutual antagonism regulates the gain of the cortex to achieve sensitivity to specific weak stimuli without compromising network stability."
}- source_refs
[
"paper:paper-f2c584233c97"
]
- evidence_refs
[
{
"ref": "paper:paper-f2c584233c97"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}