Whole-cell membrane-potential recording of genetically-defined excitatory and i…

Whole-cell membrane-potential recording of genetically-defined excitatory and inhibitory cell types across mouse barrel-cortex depth in awake head-restrained mice during quiet wakefulness, free whisking and active touch shows that excitatory pyramids (especially superficial) are hyperpolarized with low firing rates, PV+ interneurons fire at the highest rates and respond strongly to touch, VIP+ are excited at whisking onset and after-touch with delay, and SST+ show whisking-onset hyperpolarization restricted to superficial layers — confirming layer- and cell-type-dependence of active-touch dyna

{
  "n": 0,
  "doi": "10.1371/journal.pone.0287174",
  "claim": "Whole-cell membrane-potential recording of genetically-defined excitatory and inhibitory cell types across mouse barrel-cortex depth in awake head-restrained mice during quiet wakefulness, free whisking and active touch shows that excitatory pyramids (especially superficial) are hyperpolarized with low firing rates, PV+ interneurons fire at the highest rates and respond strongly to touch, VIP+ are excited at whisking onset and after-touch with delay, and SST+ show whisking-onset hyperpolarization restricted to superficial layers — confirming layer- and cell-type-dependence of active-touch dynamics in mouse cortex.",
  "cite_key": "Kiritani2023",
  "evidence": "Two-photon-targeted whole-cell membrane-potential recordings across multiple cortical depths of mouse barrel-cortex genetically-defined excitatory and inhibitory cell types in awake head-restrained mice.",
  "effect_size": "qualitative — cell-type-resolved Vm dynamics during whisking/touch in mouse S1",
  "text_access": "fulltext",
  "study_system": "awake mouse barrel cortex pyramidal, PV+, VIP+, SST+ cells across depth",
  "argument_role": "supporting",
  "replication_status": "single_study",
  "claim_source_sentence": "Excitatory neurons, especially those located superficially, were hyperpolarized with low action potential firing rates relative to inhibitory neurons. Parvalbumin-expressing inhibitory neurons on average fired at the highest rates, responding strongly and rapidly to whisker touch. Vasoactive intestinal peptide-expressing inhibitory neurons were excited during whisking, but responded to active touch only after a delay. Somatostatin-expressing inhibitory neurons had the smallest membrane potential fluctuations and exhibited hyperpolarising responses at whisking onset for superficial, but not deep, neurons",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Excitatory neurons, especially those located superficially, were hyperpolarized with low action potential firing rates relative to inhibitory neurons"
}

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Excitatory neurons, especially those located superficially, were hyperpolarized with low action potential firing rates relative to inhibitory neurons. Parvalbumin-expressing inhibitory neurons on average fired at the highest rates, responding strongly and rapidly to whisker touch. Vasoactive intestinal peptide-expressing inhibitory neurons were excited during whisking, but responded to active touch only after a dela...

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