Version history

{
  "scope": "awake mouse barrel cortex pyramidal, PV+, VIP+, SST+ cells across depth",
  "claim_text": "Whole-cell membrane-potential recording of genetically-defined excitatory and inhibitory cell types across mouse barrel-cortex depth in awake head-restrained mice during quiet wakefulness, free whisking and active touch shows that excitatory pyramids (especially superficial) are hyperpolarized with low firing rates, PV+ interneurons fire at the highest rates and respond strongly to touch, VIP+ are excited at whisking onset and after-touch with delay, and SST+ show whisking-onset hyperpolarization restricted to superficial layers — confirming layer- and cell-type-dependence of active-touch dyna",
  "raw_fields": {
    "n": 0,
    "doi": "10.1371/journal.pone.0287174",
    "claim": "Whole-cell membrane-potential recording of genetically-defined excitatory and inhibitory cell types across mouse barrel-cortex depth in awake head-restrained mice during quiet wakefulness, free whisking and active touch shows that excitatory pyramids (especially superficial) are hyperpolarized with low firing rates, PV+ interneurons fire at the highest rates and respond strongly to touch, VIP+ are excited at whisking onset and after-touch with delay, and SST+ show whisking-onset hyperpolarization restricted to superficial layers — confirming layer- and cell-type-dependence of active-touch dynamics in mouse cortex.",
    "cite_key": "Kiritani2023",
    "evidence": "Two-photon-targeted whole-cell membrane-potential recordings across multiple cortical depths of mouse barrel-cortex genetically-defined excitatory and inhibitory cell types in awake head-restrained mice.",
    "effect_size": "qualitative — cell-type-resolved Vm dynamics during whisking/touch in mouse S1",
    "text_access": "fulltext",
    "study_system": "awake mouse barrel cortex pyramidal, PV+, VIP+, SST+ cells across depth",
    "argument_role": "supporting",
    "replication_status": "single_study",
    "claim_source_sentence": "Excitatory neurons, especially those located superficially, were hyperpolarized with low action potential firing rates relative to inhibitory neurons. Parvalbumin-expressing inhibitory neurons on average fired at the highest rates, responding strongly and rapidly to whisker touch. Vasoactive intestinal peptide-expressing inhibitory neurons were excited during whisking, but responded to active touch only after a delay. Somatostatin-expressing inhibitory neurons had the smallest membrane potential fluctuations and exhibited hyperpolarising responses at whisking onset for superficial, but not deep, neurons",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Excitatory neurons, especially those located superficially, were hyperpolarized with low action potential firing rates relative to inhibitory neurons"
  },
  "section_id": "section_07",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json",
  "effect_size": "qualitative — cell-type-resolved Vm dynamics during whisking/touch in mouse S1",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
  "source_kind": "review_finding",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:paper-441f7b6f6923"
  ],
  "source_span": "Excitatory neurons, especially those located superficially, were hyperpolarized with low action potential firing rates relative to inhibitory neurons. Parvalbumin-expressing inhibitory neurons on average fired at the highest rates, responding strongly and rapidly to whisker touch. Vasoactive intestinal peptide-expressing inhibitory neurons were excited during whisking, but responded to active touch only after a dela...",
  "study_system": "awake mouse barrel cortex pyramidal, PV+, VIP+, SST+ cells across depth",
  "evidence_refs": [
    {
      "ref": "paper:paper-441f7b6f6923"
    }
  ],
  "section_title": "7. Cell-type-specific E→E motifs in mouse — IT vs PT vs CT pyramidal projection classes; L5 thick-tufted recurrence; Patch-seq and Allen mouse-cortex taxonomy intersections; transcriptomic-type-specific connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Two-photon-targeted whole-cell membrane-potential recordings across multiple cortical depths of mouse barrel-cortex genetically-defined excitatory and inhibitory cell types in awake head-restrained mice.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "single_study",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}