Long-range all-optical mapping in mouse V1 reveals that LM→V1 feedback is spati…

Long-range all-optical mapping in mouse V1 reveals that LM→V1 feedback is spatially organized in retinotopy: aligned feedback is suppressive whereas retinotopically offset feedback is facilitating and engages V1 apical-tuft dendritic regenerative events.

{
  "n": 0,
  "doi": "10.1038/s41586-023-06007-6",
  "claim": "Long-range all-optical mapping in mouse V1 reveals that LM→V1 feedback is spatially organized in retinotopy: aligned feedback is suppressive whereas retinotopically offset feedback is facilitating and engages V1 apical-tuft dendritic regenerative events.",
  "cite_key": "Fisek2023",
  "evidence": "Two-photon optogenetic activation of LM projection neurons paired with imaging of V1 dendritic and somatic calcium signals; retinotopic offset of stimulus and feedback source manipulated.",
  "effect_size": "Retinotopically aligned LM→V1 feedback: net suppressive. Offset feedback: net facilitating, dendritic Ca events present.",
  "text_access": "abstract_only",
  "study_system": "mouse V1 + lateromedial area; long-range all-optical (2-photon optogenetics + imaging) connectivity mapping",
  "argument_role": "supporting",
  "replication_status": "single_study",
  "claim_source_sentence": "Here we use long-range all-optical connectivity mapping in mice to show that feedback influence from the lateromedial higher visual area (LM) to the primary visual cortex (V1) is spatially organized.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "When the source and target of feedback represent the same area of visual space, feedback is relatively suppressive. By contrast, when the source is offset from the target in visual space, feedback is relatively facilitating."
}

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