Details
- scope
- mouse hippocampal PV interneurons
- claim_text
- PV interneurons show high transcriptomic similarity across morphologically distinct subtypes, with continuous rather than discrete transcriptomic landscapes.
- section_id
- section_02_evidence_package
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_02_evidence_package.json
- effect_size
- few genes divergent between morphological types; uniform CAM profile
- review_repo
- ComputationalReviewPV
- section_ref
- wiki_page:computationalreviewpv-02
- source_kind
- review_finding
- source_path
- evidence/section_02_evidence_package.json
- source_span
- Overall, we find high transcriptomic similarity among PV-INs, with few genes showing divergent expression between morphologically different types.
- study_system
- mouse hippocampal PV interneurons
- section_title
- Molecular Identity and Transcriptomic Taxonomy
- evidence_summary
- Single-cell RNA-seq in morphologically identified PV interneurons in hippocampus showed uniform transcriptomic and biophysical profiles despite anatomical differences.
- review_bundle_ref
- analysis_bundle:ab-e6261c8263e7
- replication_status
- replication_unknown
- review_package_ref
- analysis_bundle:ab-e6261c8263e7
- source_artifact_ref
- wiki_page:computationalreviewpv-02
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_02_evidence_package.json
- commit_sha
- df9fc7e8d455b084152c9d713558dae0013cef21
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (4)
- raw_fields
{ "n": 0, "doi": "10.1038/s41467-020-20328-4", "claim": "PV interneurons show high transcriptomic similarity across morphologically distinct subtypes, with continuous rather than discrete transcriptomic landscapes.", "evidence": "Single-cell RNA-seq in morphologically identified PV interneurons in hippocampus showed uniform transcriptomic and biophysical profiles despite anatomical differences.", "effect_size": "few genes divergent between morphological types; uniform CAM profile", "text_access": "fulltext", "study_system": "mouse hippocampal PV interneurons", "replication_status": "replication_unknown", "claim_source_sentence": "Overall, we find high transcriptomic similarity among PV-INs, with few genes showing divergent expression between morphologically different types.", "replication_evidence_dois": [], "effect_size_source_sentence": "PV-INs show a uniform synaptic cell adhesion molecule (CAM) profile, suggesting that CAM expression in mature PV cells does not reflect wiring specificity after development." }- source_refs
[ "paper:paper-81b583f41ed6" ]
- evidence_refs
[ { "ref": "paper:paper-81b583f41ed6" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV" }