- claim_text
In mouse barrel cortex, higher-order thalamic POm activation evokes layer-specific microcircuit responses: deep pyramids receive fast PV-mediated feedforward inhibition, superficial pyramids receive slow inhibition from 5HT3aR+ (including VIP) interneurons, and SST+ neurons do not receive direct POm input and have suppressed activity during POm stimulation.
- raw_fields
{
"n": null,
"doi": "10.1093/cercor/bhx044",
"claim": "In mouse barrel cortex, higher-order thalamic POm activation evokes layer-specific microcircuit responses: deep pyramids receive fast PV-mediated feedforward inhibition, superficial pyramids receive slow inhibition from 5HT3aR+ (including VIP) interneurons, and SST+ neurons do not receive direct POm input and have suppressed activity during POm stimulation.",
"title": null,
"cite_key": "Audette2018",
"evidence": "Channelrhodopsin photo-stimulation of POm + cell-type-targeted whole-cell recordings in S1 slices.",
"effect_size": "Qualitative; differential layer-specific thalamic targeting of GABAergic interneuron classes.",
"text_access": "abstract_only",
"study_system": "mouse S1 barrel cortex slice",
"_source_cluster": "cluster_05_synaptic_connectivity",
"replication_status": "replicated",
"_source_cluster_index": 12,
"claim_source_sentence": "Evoked activity in pyramidal neurons from deep layers is fast and synchronized by rapid feedforward inhibition from GABAergic parvalbumin-expressing neurons, and activity in superficial layers is weaker and prolonged, facilitated by slow inhibition from GABAergic neurons expressing the 5HT3a receptor.",
"replication_evidence_dois": [
"10.1016/j.neuron.2018.10.049"
],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-9a47e0f1c3a7"
]
- source_span
Evoked activity in pyramidal neurons from deep layers is fast and synchronized by rapid feedforward inhibition from GABAergic parvalbumin-expressing neurons, and activity in superficial layers is weaker and prolonged, facilitated by slow inhibition from GABAergic neurons expressing the 5HT3a receptor.
- evidence_refs
[
{
"ref": "paper:paper-9a47e0f1c3a7"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}