Version history

{
  "scope": "mouse S1 barrel cortex slice",
  "claim_text": "In mouse barrel cortex, higher-order thalamic POm activation evokes layer-specific microcircuit responses: deep pyramids receive fast PV-mediated feedforward inhibition, superficial pyramids receive slow inhibition from 5HT3aR+ (including VIP) interneurons, and SST+ neurons do not receive direct POm input and have suppressed activity during POm stimulation.",
  "raw_fields": {
    "n": null,
    "doi": "10.1093/cercor/bhx044",
    "claim": "In mouse barrel cortex, higher-order thalamic POm activation evokes layer-specific microcircuit responses: deep pyramids receive fast PV-mediated feedforward inhibition, superficial pyramids receive slow inhibition from 5HT3aR+ (including VIP) interneurons, and SST+ neurons do not receive direct POm input and have suppressed activity during POm stimulation.",
    "title": null,
    "cite_key": "Audette2018",
    "evidence": "Channelrhodopsin photo-stimulation of POm + cell-type-targeted whole-cell recordings in S1 slices.",
    "effect_size": "Qualitative; differential layer-specific thalamic targeting of GABAergic interneuron classes.",
    "text_access": "abstract_only",
    "study_system": "mouse S1 barrel cortex slice",
    "_source_cluster": "cluster_05_synaptic_connectivity",
    "replication_status": "replicated",
    "_source_cluster_index": 12,
    "claim_source_sentence": "Evoked activity in pyramidal neurons from deep layers is fast and synchronized by rapid feedforward inhibition from GABAergic parvalbumin-expressing neurons, and activity in superficial layers is weaker and prolonged, facilitated by slow inhibition from GABAergic neurons expressing the 5HT3a receptor.",
    "replication_evidence_dois": [
      "10.1016/j.neuron.2018.10.049"
    ],
    "effect_size_source_sentence": null
  },
  "section_id": "section_06",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json",
  "effect_size": "Qualitative; differential layer-specific thalamic targeting of GABAergic interneuron classes.",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-06-synaptic-properties",
  "source_kind": "review_finding",
  "source_path": "evidence/section_06_evidence_package.json",
  "source_refs": [
    "paper:paper-9a47e0f1c3a7"
  ],
  "source_span": "Evoked activity in pyramidal neurons from deep layers is fast and synchronized by rapid feedforward inhibition from GABAergic parvalbumin-expressing neurons, and activity in superficial layers is weaker and prolonged, facilitated by slow inhibition from GABAergic neurons expressing the 5HT3a receptor.",
  "study_system": "mouse S1 barrel cortex slice",
  "evidence_refs": [
    {
      "ref": "paper:paper-9a47e0f1c3a7"
    }
  ],
  "section_title": "Synaptic Properties and Connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Channelrhodopsin photo-stimulation of POm + cell-type-targeted whole-cell recordings in S1 slices.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-06-synaptic-properties",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}