Version history

{
  "scope": "rats; cell-type specific optogenetics + fMRI",
  "claim_text": "Optogenetic activation of D1 versus D2 receptor-expressing striatal neurons drives opposing whole-brain BOLD responses in downstream basal ganglia–thalamic targets, providing direct cell-type specific evidence for the canonical opponent-pathway model.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1016/j.neuron.2016.06.010",
    "claim": "Optogenetic activation of D1 versus D2 receptor-expressing striatal neurons drives opposing whole-brain BOLD responses in downstream basal ganglia–thalamic targets, providing direct cell-type specific evidence for the canonical opponent-pathway model.",
    "cite_key": "Lee2016",
    "evidence": "Optogenetic stimulation of D1 vs D2 SPNs combined with whole-brain fMRI; positive/negative BOLD signals correlated with single-unit increases/decreases in striatum, thalamus, GPi, STN.",
    "effect_size": "",
    "text_access": "abstract_only",
    "study_system": "rats; cell-type specific optogenetics + fMRI",
    "source_cluster_id": "cluster_01",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "Excitation of either inhibitory population evoked robust positive BOLD signals within striatum, while downstream regions exhibited significantly different and generally opposing responses consistent with-though not easily predicted from-contemporary models of basal ganglia function.",
    "replication_evidence_dois": [
      "10.1016/j.neuron.2015.05.008",
      "10.1038/nature11846"
    ],
    "effect_size_source_sentence": null
  },
  "section_id": "section_01",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_01_evidence_package.json",
  "effect_size": "",
  "review_repo": "ComputationalReviewLoops",
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  "source_kind": "review_finding",
  "source_path": "evidence/section_01_evidence_package.json",
  "source_refs": [
    "paper:paper-b849240e219b"
  ],
  "source_span": "Excitation of either inhibitory population evoked robust positive BOLD signals within striatum, while downstream regions exhibited significantly different and generally opposing responses consistent with-though not easily predicted from-contemporary models of basal ganglia function.",
  "study_system": "rats; cell-type specific optogenetics + fMRI",
  "evidence_refs": [
    {
      "ref": "paper:paper-b849240e219b"
    }
  ],
  "section_title": "Introduction: Swanson's Loop Hypothesis and Its Intellectual Lineage",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
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  "evidence_summary": "Optogenetic stimulation of D1 vs D2 SPNs combined with whole-brain fMRI; positive/negative BOLD signals correlated with single-unit increases/decreases in striatum, thalamus, GPi, STN.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-01",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_01_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}