- claim_text
Optogenetic activation of D1 versus D2 receptor-expressing striatal neurons drives opposing whole-brain BOLD responses in downstream basal ganglia–thalamic targets, providing direct cell-type specific evidence for the canonical opponent-pathway model.
- raw_fields
{
"n": 0,
"doi": "10.1016/j.neuron.2016.06.010",
"claim": "Optogenetic activation of D1 versus D2 receptor-expressing striatal neurons drives opposing whole-brain BOLD responses in downstream basal ganglia–thalamic targets, providing direct cell-type specific evidence for the canonical opponent-pathway model.",
"cite_key": "Lee2016",
"evidence": "Optogenetic stimulation of D1 vs D2 SPNs combined with whole-brain fMRI; positive/negative BOLD signals correlated with single-unit increases/decreases in striatum, thalamus, GPi, STN.",
"effect_size": "",
"text_access": "abstract_only",
"study_system": "rats; cell-type specific optogenetics + fMRI",
"source_cluster_id": "cluster_01",
"replication_status": "independently_replicated",
"claim_source_sentence": "Excitation of either inhibitory population evoked robust positive BOLD signals within striatum, while downstream regions exhibited significantly different and generally opposing responses consistent with-though not easily predicted from-contemporary models of basal ganglia function.",
"replication_evidence_dois": [
"10.1016/j.neuron.2015.05.008",
"10.1038/nature11846"
],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-b849240e219b"
]
- source_span
Excitation of either inhibitory population evoked robust positive BOLD signals within striatum, while downstream regions exhibited significantly different and generally opposing responses consistent with-though not easily predicted from-contemporary models of basal ganglia function.
- evidence_refs
[
{
"ref": "paper:paper-b849240e219b"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}