Version history

{
  "scope": "Mouse cortex; all-optical transgenic for soma-targeted opsin and calcium indicator",
  "claim_text": "Read-out plus write-in of cell-specific firing rates in mouse cortex requires per-cell calibration of photostimulation and a co-expressed soma-targeted opsin/indicator transgenic — a methodological pre-condition that current all-optical experiments often lack.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1016/j.celrep.2023.112909",
    "claim": "Read-out plus write-in of cell-specific firing rates in mouse cortex requires per-cell calibration of photostimulation and a co-expressed soma-targeted opsin/indicator transgenic — a methodological pre-condition that current all-optical experiments often lack.",
    "cite_key": "Bounds2023",
    "evidence": "Explicit statement of an outstanding limit of all-optical mouse-cortex interrogation — directly addresses cluster_14's resolution-limit topic.",
    "effect_size": null,
    "text_access": "abstract_only",
    "study_system": "Mouse cortex; all-optical transgenic for soma-targeted opsin and calcium indicator",
    "argument_role": "supporting",
    "replication_status": "single-study",
    "claim_source_sentence": "However, these techniques are unable to test how patterns of activity across a population contribute to computation because of an inability to both read and write cell-specific firing rates.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_15",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_15_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-15-methods-limits",
  "source_kind": "review_finding",
  "source_path": "evidence/section_15_evidence_package.json",
  "source_refs": [
    "paper:paper-f323df6178be"
  ],
  "source_span": "However, these techniques are unable to test how patterns of activity across a population contribute to computation because of an inability to both read and write cell-specific firing rates.",
  "study_system": "Mouse cortex; all-optical transgenic for soma-targeted opsin and calcium indicator",
  "evidence_refs": [
    {
      "ref": "paper:paper-f323df6178be"
    }
  ],
  "section_title": "15. Methodological limits and emerging tools — what current mouse-cortex tools cannot yet measure about E→E recurrence (subthreshold network activity, fast plasticity in vivo, millimetre-scale dynamic connectomes), and what is on the near horizon",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Explicit statement of an outstanding limit of all-optical mouse-cortex interrogation — directly addresses cluster_14's resolution-limit topic.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "single-study",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-15-methods-limits",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_15_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}