Read-out plus write-in of cell-specific firing rates in mouse cortex requires p…

Read-out plus write-in of cell-specific firing rates in mouse cortex requires per-cell calibration of photostimulation and a co-expressed soma-targeted opsin/indicator transgenic — a methodological pre-condition that current all-optical experiments often lack.

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  "doi": "10.1016/j.celrep.2023.112909",
  "claim": "Read-out plus write-in of cell-specific firing rates in mouse cortex requires per-cell calibration of photostimulation and a co-expressed soma-targeted opsin/indicator transgenic — a methodological pre-condition that current all-optical experiments often lack.",
  "cite_key": "Bounds2023",
  "evidence": "Explicit statement of an outstanding limit of all-optical mouse-cortex interrogation — directly addresses cluster_14's resolution-limit topic.",
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15. Methodological limits and emerging tools — what current mouse-cortex tools cannot yet measure about E→E recurrence (subthreshold network activity, fast plasticity in vivo, millimetre-scale dynamic connectomes), and what is on the near horizon

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