Version history

{
  "scope": "mouse motor cortex, thalamus, subiculum, hypothalamus projection neurons",
  "claim_text": "Brain-wide light-sheet imaging and manual reconstruction of 1,000+ individual projection neurons in mouse motor cortex, thalamus, subiculum and hypothalamus identifies previously undescribed projection-neuron subtypes and reveals organizational principles of long-range corticocortical and cortico-subcortical wiring (e.g. discrete IT, PT, CT subtype axonal patterns within mouse M1 L5).",
  "raw_fields": {
    "n": 1000,
    "doi": "10.1016/j.cell.2019.07.042",
    "claim": "Brain-wide light-sheet imaging and manual reconstruction of 1,000+ individual projection neurons in mouse motor cortex, thalamus, subiculum and hypothalamus identifies previously undescribed projection-neuron subtypes and reveals organizational principles of long-range corticocortical and cortico-subcortical wiring (e.g. discrete IT, PT, CT subtype axonal patterns within mouse M1 L5).",
    "cite_key": "Winnubst2019",
    "evidence": "High-throughput serial-block-face two-photon imaging plus manual single-neuron tracing of mouse cortical and subcortical projection neurons.",
    "effect_size": "quantitative — >1,000 reconstructed neurons across 4 brain regions",
    "text_access": "fulltext",
    "study_system": "mouse motor cortex, thalamus, subiculum, hypothalamus projection neurons",
    "argument_role": "supporting",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "we reconstructed more than 1,000 projection neurons in the motor cortex, thalamus, subiculum, and hypothalamus. Together, the reconstructed neurons comprise more than 85 meters of axonal length and are available in a searchable online database. Axonal shapes revealed previously unknown subtypes of projection neurons and suggest organizational principles of long-range connectivity",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [
      "10.1038/s41586-021-04020-1"
    ],
    "effect_size_source_sentence": "more than 1,000 projection neurons in the motor cortex, thalamus, subiculum, and hypothalamus"
  },
  "section_id": "section_07",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json",
  "effect_size": "quantitative — >1,000 reconstructed neurons across 4 brain regions",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
  "source_kind": "review_finding",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:041efce6-fc13-4416-8aca-e196f82f3d70"
  ],
  "source_span": "we reconstructed more than 1,000 projection neurons in the motor cortex, thalamus, subiculum, and hypothalamus. Together, the reconstructed neurons comprise more than 85 meters of axonal length and are available in a searchable online database. Axonal shapes revealed previously unknown subtypes of projection neurons and suggest organizational principles of long-range connectivity",
  "study_system": "mouse motor cortex, thalamus, subiculum, hypothalamus projection neurons",
  "evidence_refs": [
    {
      "ref": "paper:041efce6-fc13-4416-8aca-e196f82f3d70"
    }
  ],
  "section_title": "7. Cell-type-specific E→E motifs in mouse — IT vs PT vs CT pyramidal projection classes; L5 thick-tufted recurrence; Patch-seq and Allen mouse-cortex taxonomy intersections; transcriptomic-type-specific connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "High-throughput serial-block-face two-photon imaging plus manual single-neuron tracing of mouse cortical and subcortical projection neurons.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}