Details

scope
mouse (Mus musculus); whole-brain CBGT loop
claim_text
Whole-mouse-brain anterograde mapping reveals six parallel cortico-basal ganglia-thalamic subnetworks (rather than three) that close back onto their originating corticostriatal neurons in a bona fide closed-loop topology.
section_id
section_16
source_url
https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_16_evidence_package.json
effect_size
6 parallel CBGT subnetworks; 14 SNr domains; 36 GPe domains; 29 striatal domains
review_repo
ComputationalReviewLoops
section_ref
wiki_page:computationalreviewloops-16
source_kind
review_finding
source_path
evidence/section_16_evidence_package.json
source_span
Previous efforts to refine the three-channel model have postulated a number of specific parallel subnetworks 1 , 11 .
study_system
mouse (Mus musculus); whole-brain CBGT loop
section_title
Synthesis: Reassessing the Generalized Loop Model 25 Years On
evidence_summary
Multi-synaptic anterograde viral tracing of striatal output via GPe, SNr, and thalamus across whole mouse brain; 29 striatal domains, 14 SNr domains, 36 GPe domains.
review_bundle_ref
analysis_bundle:ab-d49e54403ef9
replication_status
replication_unknown
review_package_ref
analysis_bundle:ab-d49e54403ef9
source_artifact_ref
wiki_page:computationalreviewloops-16
origin_url
https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_16_evidence_package.json
commit_sha
0632aae8abc141909207fe91f6349b9e36489c3b
created_by
persona-jerome-lecoq-gbo-neuroscience
repository_url
https://github.com/AllenNeuralDynamics/ComputationalReviewLoops
Raw fields (4)
raw_fields
{
  "n": null,
  "doi": "10.1038/s41586-021-03993-3",
  "claim": "Whole-mouse-brain anterograde mapping reveals six parallel cortico-basal ganglia-thalamic subnetworks (rather than three) that close back onto their originating corticostriatal neurons in a bona fide closed-loop topology.",
  "cite_key": "Foster2021",
  "evidence": "Multi-synaptic anterograde viral tracing of striatal output via GPe, SNr, and thalamus across whole mouse brain; 29 striatal domains, 14 SNr domains, 36 GPe domains.",
  "effect_size": "6 parallel CBGT subnetworks; 14 SNr domains; 36 GPe domains; 29 striatal domains",
  "text_access": "fulltext",
  "study_system": "mouse (Mus musculus); whole-brain CBGT loop",
  "source_cluster_id": "cluster_01",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "Previous efforts to refine the three-channel model have postulated a number of specific parallel subnetworks 1 , 11 .",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Accordingly, we identify 14 SNr and 36 GPe domains and a direct cortico-SNr projection."
}
source_refs
[
  "paper:paper-79995db40fc1"
]
evidence_refs
[
  {
    "ref": "paper:paper-79995db40fc1"
  }
]
source_policy
{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}

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