Clinically effective subthalamic stimulation activates the cerebral cortex at ~…

{
  "n": 5,
  "doi": "10.1002/mds.25025",
  "claim": "Clinically effective subthalamic stimulation activates the cerebral cortex at ~1 ms latency, most likely by antidromic activation of cortico-STN axons.",
  "cite_key": "Walker2012",
  "evidence": "EEG recordings during STN-DBS in 5 PD subjects (6 hemispheres); novel anode/cathode swap and ERP summation suppress stimulation artifact and reveal R1 (~1.0 ± 0.4 ms), R2 (~5.7 ms), R3 (~22.2 ms).",
  "effect_size": "R1 latency 1.0 ± 0.4 ms",
  "text_access": "abstract_only",
  "study_system": "PD STN-DBS subjects (5 subjects, 6 hemispheres) with intra-operative EEG",
  "source_cluster_id": "cluster_13",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "We conclude that clinically effective subthalamic brain stimulation in humans with PD activates the cerebral cortex at 1 ms after stimulus onset, most likely by antidromic activation.",
  "replication_evidence_dois": [
    "10.1007/s00702-026-03137-9",
    "10.1016/j.brs.2026.103061"
  ],
  "effect_size_source_sentence": "We found that subthalamic brain stimulation at 20 Hz activates the somatosensory cortex at discrete latencies (mean latencies: 1.0 ± 0.4, 5.7 ± 1.1, and 22.2 ± 1.8 ms, denoted as R1, R2, and R3, respectively)."
}

[
  "paper:paper-f58ca120c853"
]

[
  {
    "ref": "paper:paper-f58ca120c853"
  }
]

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