Version history

{
  "scope": "PD STN-DBS subjects (5 subjects, 6 hemispheres) with intra-operative EEG",
  "claim_text": "Clinically effective subthalamic stimulation activates the cerebral cortex at ~1 ms latency, most likely by antidromic activation of cortico-STN axons.",
  "raw_fields": {
    "n": 5,
    "doi": "10.1002/mds.25025",
    "claim": "Clinically effective subthalamic stimulation activates the cerebral cortex at ~1 ms latency, most likely by antidromic activation of cortico-STN axons.",
    "cite_key": "Walker2012",
    "evidence": "EEG recordings during STN-DBS in 5 PD subjects (6 hemispheres); novel anode/cathode swap and ERP summation suppress stimulation artifact and reveal R1 (~1.0 ± 0.4 ms), R2 (~5.7 ms), R3 (~22.2 ms).",
    "effect_size": "R1 latency 1.0 ± 0.4 ms",
    "text_access": "abstract_only",
    "study_system": "PD STN-DBS subjects (5 subjects, 6 hemispheres) with intra-operative EEG",
    "source_cluster_id": "cluster_13",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "We conclude that clinically effective subthalamic brain stimulation in humans with PD activates the cerebral cortex at 1 ms after stimulus onset, most likely by antidromic activation.",
    "replication_evidence_dois": [
      "10.1007/s00702-026-03137-9",
      "10.1016/j.brs.2026.103061"
    ],
    "effect_size_source_sentence": "We found that subthalamic brain stimulation at 20 Hz activates the somatosensory cortex at discrete latencies (mean latencies: 1.0 ± 0.4, 5.7 ± 1.1, and 22.2 ± 1.8 ms, denoted as R1, R2, and R3, respectively)."
  },
  "section_id": "section_14",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_14_evidence_package.json",
  "effect_size": "R1 latency 1.0 ± 0.4 ms",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-14",
  "source_kind": "review_finding",
  "source_path": "evidence/section_14_evidence_package.json",
  "source_refs": [
    "paper:paper-f58ca120c853"
  ],
  "source_span": "We conclude that clinically effective subthalamic brain stimulation in humans with PD activates the cerebral cortex at 1 ms after stimulus onset, most likely by antidromic activation.",
  "study_system": "PD STN-DBS subjects (5 subjects, 6 hemispheres) with intra-operative EEG",
  "evidence_refs": [
    {
      "ref": "paper:paper-f58ca120c853"
    }
  ],
  "section_title": "Loop Dysfunction in Neurological and Psychiatric Disease",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "EEG recordings during STN-DBS in 5 PD subjects (6 hemispheres); novel anode/cathode swap and ERP summation suppress stimulation artifact and reveal R1 (~1.0 ± 0.4 ms), R2 (~5.7 ms), R3 (~22.2 ms).",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-14",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_14_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}