A 16.4 g miniaturized widefield voltage-imaging microscope can record Voltron2…

A 16.4 g miniaturized widefield voltage-imaging microscope can record Voltron2 spikes in vivo at 530 Hz with peak-to-noise ratio >3 across a 250 µm field of view — concretely bounding the present-day yield/speed/FOV envelope of head-mounted voltage imaging.

{
  "n": 0,
  "doi": "10.1364/boe.576516",
  "claim": "A 16.4 g miniaturized widefield voltage-imaging microscope can record Voltron2 spikes in vivo at 530 Hz with peak-to-noise ratio >3 across a 250 µm field of view — concretely bounding the present-day yield/speed/FOV envelope of head-mounted voltage imaging.",
  "cite_key": "Saladrigas2026",
  "evidence": "Quantitative ceiling on freely-moving voltage imaging — directly relevant to cluster_14's discussion of what voltage imaging cannot yet measure.",
  "effect_size": "NA 0.6; 250 µm FOV; 1.3–1.6 mm working distance; 16.4 g; 530 Hz frame rate; SNR >3",
  "text_access": "abstract_only",
  "study_system": "In vivo mouse; miniaturized widefield voltage microscope with Voltron2",
  "argument_role": "supporting",
  "replication_status": "single-study",
  "claim_source_sentence": "We show it is capable of imaging <i>in vivo</i> voltage spikes from Voltron2 with a spike peak-to-noise ratio >3 at a framerate of 530 Hz.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "We present a miniaturized microscope designed for voltage imaging, with a numerical aperture of 0.6, a 250 µm field of view, and a 1.3-1.6 mm working distance that weighs 16.4 g."
}

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