Version history

{
  "scope": "mouse somatosensory (barrel) cortex in vivo, anesthetized and awake; L2/3 pyramidal optogenetic manipulation",
  "claim_text": "Optogenetic activation of mouse barrel-cortex L2/3 pyramidal neurons amplifies sensory-evoked L5 responses with a velocity-dependent gain that scales with stimulus speed.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1016/j.celrep.2018.08.038",
    "claim": "Optogenetic activation of mouse barrel-cortex L2/3 pyramidal neurons amplifies sensory-evoked L5 responses with a velocity-dependent gain that scales with stimulus speed.",
    "cite_key": "Quiquempoix2018",
    "evidence": "Cell-type-specific reversible optogenetic activation/inactivation of L2/3 pyramidal neurons during whisker stimulation in mouse S1; in vivo recordings.",
    "effect_size": "Velocity-dependent amplification of L5 sensory responses by L2/3 activation.",
    "text_access": "abstract_only",
    "study_system": "mouse somatosensory (barrel) cortex in vivo, anesthetized and awake; L2/3 pyramidal optogenetic manipulation",
    "argument_role": "supporting",
    "replication_status": "contested",
    "claim_source_sentence": "Using cell type-specific and reversible optogenetic manipulations in the somatosensory cortex of both anesthetized and awake mice, we demonstrate that L2/3 pyramidal neurons play a major role in amplifying sensory-evoked responses in L5 neurons. The amplification effect scales with the velocity of the sensory stimulus, indicating that L2/3 pyramidal neurons implement gain control in deep-layer neurons.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [
      "10.1523/JNEUROSCI.1459-18.2018"
    ],
    "effect_size_source_sentence": null
  },
  "section_id": "section_04",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "effect_size": "Velocity-dependent amplification of L5 sensory responses by L2/3 activation.",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "source_kind": "review_finding",
  "source_path": "evidence/section_04_evidence_package.json",
  "source_refs": [
    "paper:paper-9360095f1258"
  ],
  "source_span": "Using cell type-specific and reversible optogenetic manipulations in the somatosensory cortex of both anesthetized and awake mice, we demonstrate that L2/3 pyramidal neurons play a major role in amplifying sensory-evoked responses in L5 neurons. The amplification effect scales with the velocity of the sensory stimulus, indicating that L2/3 pyramidal neurons implement gain control in deep-layer neurons.",
  "study_system": "mouse somatosensory (barrel) cortex in vivo, anesthetized and awake; L2/3 pyramidal optogenetic manipulation",
  "evidence_refs": [
    {
      "ref": "paper:paper-9360095f1258"
    }
  ],
  "section_title": "4. Translaminar excitatory loops in mouse — L4→L2/3→L5→L6→L4 within the column; asymmetry of forward and backward intracortical projections",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Cell-type-specific reversible optogenetic activation/inactivation of L2/3 pyramidal neurons during whisker stimulation in mouse S1; in vivo recordings.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "contested",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}