Optogenetic activation of mouse barrel-cortex L2/3 pyramidal neurons amplifies…

{
  "n": 0,
  "doi": "10.1016/j.celrep.2018.08.038",
  "claim": "Optogenetic activation of mouse barrel-cortex L2/3 pyramidal neurons amplifies sensory-evoked L5 responses with a velocity-dependent gain that scales with stimulus speed.",
  "cite_key": "Quiquempoix2018",
  "evidence": "Cell-type-specific reversible optogenetic activation/inactivation of L2/3 pyramidal neurons during whisker stimulation in mouse S1; in vivo recordings.",
  "effect_size": "Velocity-dependent amplification of L5 sensory responses by L2/3 activation.",
  "text_access": "abstract_only",
  "study_system": "mouse somatosensory (barrel) cortex in vivo, anesthetized and awake; L2/3 pyramidal optogenetic manipulation",
  "argument_role": "supporting",
  "replication_status": "contested",
  "claim_source_sentence": "Using cell type-specific and reversible optogenetic manipulations in the somatosensory cortex of both anesthetized and awake mice, we demonstrate that L2/3 pyramidal neurons play a major role in amplifying sensory-evoked responses in L5 neurons. The amplification effect scales with the velocity of the sensory stimulus, indicating that L2/3 pyramidal neurons implement gain control in deep-layer neurons.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.1523/JNEUROSCI.1459-18.2018"
  ],
  "effect_size_source_sentence": null
}

[
  "paper:paper-9360095f1258"
]

Using cell type-specific and reversible optogenetic manipulations in the somatosensory cortex of both anesthetized and awake mice, we demonstrate that L2/3 pyramidal neurons play a major role in amplifying sensory-evoked responses in L5 neurons. The amplification effect scales with the velocity of the sensory stimulus, indicating that L2/3 pyramidal neurons implement gain control in deep-layer neurons.

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