Version history

{
  "scope": "mouse V1; in vitro slice + in vivo two-photon",
  "claim_text": "Auditory cortex (A1) projections to V1 preferentially target L1 GABAergic interneurons (excluding VIP+ cells) and suppress L2/3 VIP neurons during sound, a circuit motif that sharpens visual responses across modalities — contrary to canonical disinhibitory motifs in which VIPs are activated by long-range cortical inputs.",
  "raw_fields": {
    "n": null,
    "doi": "10.1016/j.neuron.2016.01.027",
    "claim": "Auditory cortex (A1) projections to V1 preferentially target L1 GABAergic interneurons (excluding VIP+ cells) and suppress L2/3 VIP neurons during sound, a circuit motif that sharpens visual responses across modalities — contrary to canonical disinhibitory motifs in which VIPs are activated by long-range cortical inputs.",
    "title": null,
    "cite_key": "Ibrahim2016",
    "evidence": "ChR2 photo-stimulation of A1→V1 axons + paired whole-cell recordings in slices; in vivo two-photon Ca2+ imaging of PV/SOM/VIP in L2/3.",
    "effect_size": "~10% L1 population is VIP+; VIP cells suppressed during sound at preferred orientation.",
    "text_access": "fulltext",
    "study_system": "mouse V1; in vitro slice + in vivo two-photon",
    "_source_cluster": "cluster_05_synaptic_connectivity",
    "replication_status": "single-study",
    "_source_cluster_index": 16,
    "claim_source_sentence": "As shown by response traces of example cells ( ) and summary plots of relative peak response amplitude ( , see Experimental Procedures), L1 inhibitory neurons, except those positive for VIP which only comprise ~10% of the L1 population ( ), received strong excitatory input from A",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "L1 inhibitory neurons, except those positive for VIP which only comprise ~10% of the L1 population"
  },
  "section_id": "section_06",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json",
  "effect_size": "~10% L1 population is VIP+; VIP cells suppressed during sound at preferred orientation.",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-06-synaptic-properties",
  "source_kind": "review_finding",
  "source_path": "evidence/section_06_evidence_package.json",
  "source_refs": [
    "paper:paper-1a4df0a84e5a"
  ],
  "source_span": "As shown by response traces of example cells ( ) and summary plots of relative peak response amplitude ( , see Experimental Procedures), L1 inhibitory neurons, except those positive for VIP which only comprise ~10% of the L1 population ( ), received strong excitatory input from A",
  "study_system": "mouse V1; in vitro slice + in vivo two-photon",
  "evidence_refs": [
    {
      "ref": "paper:paper-1a4df0a84e5a"
    }
  ],
  "section_title": "Synaptic Properties and Connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "ChR2 photo-stimulation of A1→V1 axons + paired whole-cell recordings in slices; in vivo two-photon Ca2+ imaging of PV/SOM/VIP in L2/3.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "single-study",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-06-synaptic-properties",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}