- claim_text
Auditory cortex (A1) projections to V1 preferentially target L1 GABAergic interneurons (excluding VIP+ cells) and suppress L2/3 VIP neurons during sound, a circuit motif that sharpens visual responses across modalities — contrary to canonical disinhibitory motifs in which VIPs are activated by long-range cortical inputs.
- raw_fields
{
"n": null,
"doi": "10.1016/j.neuron.2016.01.027",
"claim": "Auditory cortex (A1) projections to V1 preferentially target L1 GABAergic interneurons (excluding VIP+ cells) and suppress L2/3 VIP neurons during sound, a circuit motif that sharpens visual responses across modalities — contrary to canonical disinhibitory motifs in which VIPs are activated by long-range cortical inputs.",
"title": null,
"cite_key": "Ibrahim2016",
"evidence": "ChR2 photo-stimulation of A1→V1 axons + paired whole-cell recordings in slices; in vivo two-photon Ca2+ imaging of PV/SOM/VIP in L2/3.",
"effect_size": "~10% L1 population is VIP+; VIP cells suppressed during sound at preferred orientation.",
"text_access": "fulltext",
"study_system": "mouse V1; in vitro slice + in vivo two-photon",
"_source_cluster": "cluster_05_synaptic_connectivity",
"replication_status": "single-study",
"_source_cluster_index": 16,
"claim_source_sentence": "As shown by response traces of example cells ( ) and summary plots of relative peak response amplitude ( , see Experimental Procedures), L1 inhibitory neurons, except those positive for VIP which only comprise ~10% of the L1 population ( ), received strong excitatory input from A",
"replication_evidence_dois": [],
"effect_size_source_sentence": "L1 inhibitory neurons, except those positive for VIP which only comprise ~10% of the L1 population"
}- source_refs
[
"paper:paper-1a4df0a84e5a"
]
- source_span
As shown by response traces of example cells ( ) and summary plots of relative peak response amplitude ( , see Experimental Procedures), L1 inhibitory neurons, except those positive for VIP which only comprise ~10% of the L1 population ( ), received strong excitatory input from A
- evidence_refs
[
{
"ref": "paper:paper-1a4df0a84e5a"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}