Version history

{
  "scope": "mouse V1 in vivo (anesthetized); cell-type-specific optogenetics",
  "claim_text": "Systematic post-inhibitory rebound analysis in mouse V1 reveals that PV+ photostimulation produces the largest pyramidal-cell rebound spiking, that rebounds scale with visual-stimulus-driven network activation, and that many photostimulated interneurons themselves show post-activation effects distinct in polarity/timing from rebounds—a key methodological caveat for cell-type-specific circuit dissection.",
  "raw_fields": {
    "n": null,
    "doi": "10.1113/jp287265",
    "claim": "Systematic post-inhibitory rebound analysis in mouse V1 reveals that PV+ photostimulation produces the largest pyramidal-cell rebound spiking, that rebounds scale with visual-stimulus-driven network activation, and that many photostimulated interneurons themselves show post-activation effects distinct in polarity/timing from rebounds—a key methodological caveat for cell-type-specific circuit dissection.",
    "title": null,
    "cite_key": "Shapiro2025",
    "evidence": "In vivo electrophysiology + opto in PV/SST/VIP-Cre mice in V1 under isoflurane; visual stimuli paired with photostimulation.",
    "effect_size": null,
    "text_access": "abstract_only",
    "study_system": "mouse V1 in vivo (anesthetized); cell-type-specific optogenetics",
    "target_section": "section_05",
    "_source_cluster": "cluster_01_molecular_taxonomy",
    "replication_status": "replication_unknown",
    "_source_cluster_index": 119,
    "claim_source_sentence": "We found converging evidence that rebounds were largest when interneuron photostimulation was coupled with visual stimuli that strongly activate V1. Many directly photostimulated interneurons showed post-activation effects that differed from rebounds in polarity and timing. Finally, Pvalb+ photostimulation produced the largest rebounds.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_11",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_11_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-11-disease-translational",
  "source_kind": "review_finding",
  "source_path": "evidence/section_11_evidence_package.json",
  "source_refs": [
    "paper:paper-410b852f3cc3"
  ],
  "source_span": "We found converging evidence that rebounds were largest when interneuron photostimulation was coupled with visual stimuli that strongly activate V1. Many directly photostimulated interneurons showed post-activation effects that differed from rebounds in polarity and timing. Finally, Pvalb+ photostimulation produced the largest rebounds.",
  "study_system": "mouse V1 in vivo (anesthetized); cell-type-specific optogenetics",
  "evidence_refs": [
    {
      "ref": "paper:paper-410b852f3cc3"
    }
  ],
  "section_title": "Species Differences, Human Relevance, and Disease",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "In vivo electrophysiology + opto in PV/SST/VIP-Cre mice in V1 under isoflurane; visual stimuli paired with photostimulation.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-11-disease-translational",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_11_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}