- claim_text
Systematic post-inhibitory rebound analysis in mouse V1 reveals that PV+ photostimulation produces the largest pyramidal-cell rebound spiking, that rebounds scale with visual-stimulus-driven network activation, and that many photostimulated interneurons themselves show post-activation effects distinct in polarity/timing from rebounds—a key methodological caveat for cell-type-specific circuit dissection.
- raw_fields
{
"n": null,
"doi": "10.1113/jp287265",
"claim": "Systematic post-inhibitory rebound analysis in mouse V1 reveals that PV+ photostimulation produces the largest pyramidal-cell rebound spiking, that rebounds scale with visual-stimulus-driven network activation, and that many photostimulated interneurons themselves show post-activation effects distinct in polarity/timing from rebounds—a key methodological caveat for cell-type-specific circuit dissection.",
"title": null,
"cite_key": "Shapiro2025",
"evidence": "In vivo electrophysiology + opto in PV/SST/VIP-Cre mice in V1 under isoflurane; visual stimuli paired with photostimulation.",
"effect_size": null,
"text_access": "abstract_only",
"study_system": "mouse V1 in vivo (anesthetized); cell-type-specific optogenetics",
"target_section": "section_05",
"_source_cluster": "cluster_01_molecular_taxonomy",
"replication_status": "replication_unknown",
"_source_cluster_index": 119,
"claim_source_sentence": "We found converging evidence that rebounds were largest when interneuron photostimulation was coupled with visual stimuli that strongly activate V1. Many directly photostimulated interneurons showed post-activation effects that differed from rebounds in polarity and timing. Finally, Pvalb+ photostimulation produced the largest rebounds.",
"replication_evidence_dois": [],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-410b852f3cc3"
]
- source_span
We found converging evidence that rebounds were largest when interneuron photostimulation was coupled with visual stimuli that strongly activate V1. Many directly photostimulated interneurons showed post-activation effects that differed from rebounds in polarity and timing. Finally, Pvalb+ photostimulation produced the largest rebounds.
- evidence_refs
[
{
"ref": "paper:paper-410b852f3cc3"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}