Across multiple studies, 60 Hz STN-DBS consistently improves freezing of gait a…

{
  "n": 0,
  "doi": "10.1186/s40035-017-0083-7",
  "claim": "Across multiple studies, 60 Hz STN-DBS consistently improves freezing of gait and other axial symptoms compared to 130 Hz HFS, although tremor control may be reduced in some patients.",
  "cite_key": "Xie2017",
  "evidence": "Mini-review synthesizing LFS-vs-HFS outcomes across heterogeneous study designs (open-label, RCT, retrospective).",
  "effect_size": null,
  "text_access": "fulltext",
  "study_system": "Bilateral STN-DBS in PD patients (multiple cohorts, mini-review)",
  "source_cluster_id": "cluster_13",
  "replication_status": "contested",
  "claim_source_sentence": "In a\nfollow up study, they evaluated the effect of LFS on FOG\nwith and without adjusting the TEED in a double-blind\ndesign and reached the same conclusion on the beneficial\neffect of LFS on FOG and axial symptoms regardless of\nthe TEED adjustment [8], suggesting that it is the LFS that\nbrought the benefit, not the reduced energy, in that study.",
  "replication_evidence_dois": [
    "10.1212/wnl.0000000000001184",
    "10.1002/mds.26837"
  ],
  "effect_size_source_sentence": "We need to clarify that you don ’t need LFS if there is\nno FOG at HFS, as STN DBS significantly improves\nFOG at the medication Off and stimulation On condi-\ntion (mostly at routine HFS) compared with baseline at\nmedication Off in meta-analysis [32], although in a pro-\nspective study, FOG at baseline was still present in 45%\nof PD patients treated with HFS of the STN at 6 and\n12 months [3]."
}

[
  "paper:paper-2f7246e7aeea"
]

In a follow up study, they evaluated the effect of LFS on FOG with and without adjusting the TEED in a double-blind design and reached the same conclusion on the beneficial effect of LFS on FOG and axial symptoms regardless of the TEED adjustment [8], suggesting that it is the LFS that brought the benefit, not the reduced energy, in that study.

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