Version history

{
  "scope": "Bilateral STN-DBS in PD patients (multiple cohorts, mini-review)",
  "claim_text": "Across multiple studies, 60 Hz STN-DBS consistently improves freezing of gait and other axial symptoms compared to 130 Hz HFS, although tremor control may be reduced in some patients.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1186/s40035-017-0083-7",
    "claim": "Across multiple studies, 60 Hz STN-DBS consistently improves freezing of gait and other axial symptoms compared to 130 Hz HFS, although tremor control may be reduced in some patients.",
    "cite_key": "Xie2017",
    "evidence": "Mini-review synthesizing LFS-vs-HFS outcomes across heterogeneous study designs (open-label, RCT, retrospective).",
    "effect_size": null,
    "text_access": "fulltext",
    "study_system": "Bilateral STN-DBS in PD patients (multiple cohorts, mini-review)",
    "source_cluster_id": "cluster_13",
    "replication_status": "contested",
    "claim_source_sentence": "In a\nfollow up study, they evaluated the effect of LFS on FOG\nwith and without adjusting the TEED in a double-blind\ndesign and reached the same conclusion on the beneficial\neffect of LFS on FOG and axial symptoms regardless of\nthe TEED adjustment [8], suggesting that it is the LFS that\nbrought the benefit, not the reduced energy, in that study.",
    "replication_evidence_dois": [
      "10.1212/wnl.0000000000001184",
      "10.1002/mds.26837"
    ],
    "effect_size_source_sentence": "We need to clarify that you don ’t need LFS if there is\nno FOG at HFS, as STN DBS significantly improves\nFOG at the medication Off and stimulation On condi-\ntion (mostly at routine HFS) compared with baseline at\nmedication Off in meta-analysis [32], although in a pro-\nspective study, FOG at baseline was still present in 45%\nof PD patients treated with HFS of the STN at 6 and\n12 months [3]."
  },
  "section_id": "section_14",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_14_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-14",
  "source_kind": "review_finding",
  "source_path": "evidence/section_14_evidence_package.json",
  "source_refs": [
    "paper:paper-2f7246e7aeea"
  ],
  "source_span": "In a follow up study, they evaluated the effect of LFS on FOG with and without adjusting the TEED in a double-blind design and reached the same conclusion on the beneficial effect of LFS on FOG and axial symptoms regardless of the TEED adjustment [8], suggesting that it is the LFS that brought the benefit, not the reduced energy, in that study.",
  "study_system": "Bilateral STN-DBS in PD patients (multiple cohorts, mini-review)",
  "evidence_refs": [
    {
      "ref": "paper:paper-2f7246e7aeea"
    }
  ],
  "section_title": "Loop Dysfunction in Neurological and Psychiatric Disease",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "Mini-review synthesizing LFS-vs-HFS outcomes across heterogeneous study designs (open-label, RCT, retrospective).",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "contested",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-14",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_14_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}