Local pyramidal cells excite VIP and SOM interneurons at similar connection rat…

Local pyramidal cells excite VIP and SOM interneurons at similar connection rates but with opposite short-term dynamics — PC→VIP synapses are depressing while PC→SOM are facilitating; rabies tracing shows VIPs and SOMs receive comparable numbers of local presynaptic inputs from non-overlapping subnetworks; electrical coupling is restricted within (not between) VIP/SOM/PV populations.

{
  "n": 7,
  "doi": "10.1016/j.neuron.2016.02.037",
  "claim": "Local pyramidal cells excite VIP and SOM interneurons at similar connection rates but with opposite short-term dynamics — PC→VIP synapses are depressing while PC→SOM are facilitating; rabies tracing shows VIPs and SOMs receive comparable numbers of local presynaptic inputs from non-overlapping subnetworks; electrical coupling is restricted within (not between) VIP/SOM/PV populations.",
  "title": null,
  "cite_key": "Karnani2016a",
  "evidence": "Paired recordings in V1 and S1; rabies tracing of presynaptic partners; 2-photon mapping with CaMKIIα-C1V1.",
  "effect_size": "IPSP between VIP/SOM peak ~2.4±0.4 mV (SOM→VIP, n=7) and ~3.2±0.7 mV (VIP→SOM, n=7); rabies inputs: VIPs 1259±409 presynaptic cells/brain, SOMs 2535± (n=4 VIP-cre, 3 SOM-cre brains).",
  "text_access": "fulltext",
  "study_system": "mouse V1 and S1; in vitro slice + rabies + 2P optogenetics",
  "_source_cluster": "cluster_05_synaptic_connectivity",
  "replication_status": "replicated",
  "_source_cluster_index": 8,
  "claim_source_sentence": "PCs formed excitatory synapses onto VIPs and SOMs at similar rates, but synapses onto VIPs were depressing, while those onto SOMs were facilitating ( ).",
  "replication_evidence_dois": [
    "10.1038/nn.3446"
  ],
  "effect_size_source_sentence": "According to maximal IPSP amplitudes during the 50 Hz AP train ( ), connections between SOMs and VIPs tended to be the largest among all synapses tested, peaking at 2.4 ± 0.4 mV (SOM->VIP, n = 7) and 3.2 ± 0.7 mV (VIP->SOM, n = 7) hyperpolarization."
}

[
  "paper:paper-d405e5906927"
]

[
  {
    "ref": "paper:paper-d405e5906927"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}