Version history

{
  "scope": "mouse V1 and S1; in vitro slice + rabies + 2P optogenetics",
  "claim_text": "Local pyramidal cells excite VIP and SOM interneurons at similar connection rates but with opposite short-term dynamics — PC→VIP synapses are depressing while PC→SOM are facilitating; rabies tracing shows VIPs and SOMs receive comparable numbers of local presynaptic inputs from non-overlapping subnetworks; electrical coupling is restricted within (not between) VIP/SOM/PV populations.",
  "raw_fields": {
    "n": 7,
    "doi": "10.1016/j.neuron.2016.02.037",
    "claim": "Local pyramidal cells excite VIP and SOM interneurons at similar connection rates but with opposite short-term dynamics — PC→VIP synapses are depressing while PC→SOM are facilitating; rabies tracing shows VIPs and SOMs receive comparable numbers of local presynaptic inputs from non-overlapping subnetworks; electrical coupling is restricted within (not between) VIP/SOM/PV populations.",
    "title": null,
    "cite_key": "Karnani2016a",
    "evidence": "Paired recordings in V1 and S1; rabies tracing of presynaptic partners; 2-photon mapping with CaMKIIα-C1V1.",
    "effect_size": "IPSP between VIP/SOM peak ~2.4±0.4 mV (SOM→VIP, n=7) and ~3.2±0.7 mV (VIP→SOM, n=7); rabies inputs: VIPs 1259±409 presynaptic cells/brain, SOMs 2535± (n=4 VIP-cre, 3 SOM-cre brains).",
    "text_access": "fulltext",
    "study_system": "mouse V1 and S1; in vitro slice + rabies + 2P optogenetics",
    "_source_cluster": "cluster_05_synaptic_connectivity",
    "replication_status": "replicated",
    "_source_cluster_index": 8,
    "claim_source_sentence": "PCs formed excitatory synapses onto VIPs and SOMs at similar rates, but synapses onto VIPs were depressing, while those onto SOMs were facilitating ( ).",
    "replication_evidence_dois": [
      "10.1038/nn.3446"
    ],
    "effect_size_source_sentence": "According to maximal IPSP amplitudes during the 50 Hz AP train ( ), connections between SOMs and VIPs tended to be the largest among all synapses tested, peaking at 2.4 ± 0.4 mV (SOM->VIP, n = 7) and 3.2 ± 0.7 mV (VIP->SOM, n = 7) hyperpolarization."
  },
  "section_id": "section_06",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json",
  "effect_size": "IPSP between VIP/SOM peak ~2.4±0.4 mV (SOM→VIP, n=7) and ~3.2±0.7 mV (VIP→SOM, n=7); rabies inputs: VIPs 1259±409 presynaptic cells/brain, SOMs 2535± (n=4 VIP-cre, 3 SOM-cre brains).",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-06-synaptic-properties",
  "source_kind": "review_finding",
  "source_path": "evidence/section_06_evidence_package.json",
  "source_refs": [
    "paper:paper-d405e5906927"
  ],
  "source_span": "PCs formed excitatory synapses onto VIPs and SOMs at similar rates, but synapses onto VIPs were depressing, while those onto SOMs were facilitating ( ).",
  "study_system": "mouse V1 and S1; in vitro slice + rabies + 2P optogenetics",
  "evidence_refs": [
    {
      "ref": "paper:paper-d405e5906927"
    }
  ],
  "section_title": "Synaptic Properties and Connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Paired recordings in V1 and S1; rabies tracing of presynaptic partners; 2-photon mapping with CaMKIIα-C1V1.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-06-synaptic-properties",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}