PV and SST interneuron identities emerge from common MGE progenitors through di…

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scope: mouse E13 MGE (medial ganglionic eminence) interneuron progenitors
claim_text: PV and SST interneuron identities emerge from common MGE progenitors through differential opening of chromatin at distal regulatory elements, with MEF2C showing both common and subtype-specific binding patterns.
section_id: section_02_evidence_package
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_02_evidence_package.json
effect_size: more loci specifically bound by MEF2C in PV cells compared to SST
review_repo: ComputationalReviewPV
section_ref: wiki_page:computationalreviewpv-02
source_kind: review_finding
source_path: evidence/section_02_evidence_package.json
source_span: Generic interneuron features are first detected upon cell cycle exit through the opening of chromatin at distal elements.
study_system: mouse E13 MGE (medial ganglionic eminence) interneuron progenitors
section_title: Molecular Identity and Transcriptomic Taxonomy
evidence_summary: scRNA-seq, scATAC-seq, and multiomic (dual RNA/ATAC) sequencing on E13 MGE revealed early chromatin signatures of interneuron identity, with MEF2C CUT&RUN showing PV-specific binding sites.
review_bundle_ref: analysis_bundle:ab-e6261c8263e7
replication_status: replication_unknown
review_package_ref: analysis_bundle:ab-e6261c8263e7
source_artifact_ref: wiki_page:computationalreviewpv-02
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_02_evidence_package.json
commit_sha: df9fc7e8d455b084152c9d713558dae0013cef21
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV

Raw fields (4)

raw_fields

{
  "n": 0,
  "doi": "10.1038/s41586-021-03933-1",
  "claim": "PV and SST interneuron identities emerge from common MGE progenitors through differential opening of chromatin at distal regulatory elements, with MEF2C showing both common and subtype-specific binding patterns.",
  "evidence": "scRNA-seq, scATAC-seq, and multiomic (dual RNA/ATAC) sequencing on E13 MGE revealed early chromatin signatures of interneuron identity, with MEF2C CUT&RUN showing PV-specific binding sites.",
  "effect_size": "more loci specifically bound by MEF2C in PV cells compared to SST",
  "text_access": "fulltext",
  "study_system": "mouse E13 MGE (medial ganglionic eminence) interneuron progenitors",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "Generic interneuron features are first detected upon cell cycle exit through the opening of chromatin at distal elements.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "This work revealed both common and subtype-specific binding of MEF2C, with more loci specifically bound in PV cells compared to SST."
}

source_refs

[
  "paper:paper-1c4a74c94c96"
]

evidence_refs

[
  {
    "ref": "paper:paper-1c4a74c94c96"
  }
]

source_policy

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}

PV and SST interneuron identities emerge from common MGE progenitors through di…

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Replication

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